Liquid-liquid crystalline phase separation of spider silk proteins

M Landreh, H Osterholz, G Chen, SD Knight… - Communications …, 2024 - nature.com
Liquid-liquid phase separation (LLPS) of proteins can be considered an intermediate
solubility regime between disperse solutions and solid fibers. While LLPS has been …

Engineering bioinspired microfluidics; biomimetic self-healing/cleaning coating designs and unique advanced materials

A Hossain, P Rajput, Z Li, AV Soldatov… - Chemical Engineering …, 2024 - Elsevier
Advanced microfluidics coating methods, inspired by nature's self-repair and self-cleaning
mechanisms, hold promises for diverse applications across biomedical, material …

Overexpressed artificial spidroin based microneedle spinneret for 3D air spinning of hybrid spider silk

B Lin, B Gao, M Wei, S Li, Q Zhou, B He - ACS nano, 2024 - ACS Publications
Efforts have been devoted to develo** strategies for converting spider silk proteins
(spidroins) into functional silk materials. However, studies mimicking the exact natural …

Artificial Spider Silk Materials: From Molecular Design, Mesoscopic Assembly, to Macroscopic Performances

YX Shi, YJ Zhu, ZG Qian, XX **a - Advanced Functional …, 2024 - Wiley Online Library
Spider silk is one of the strongest and toughest fibrous materials available in nature. Its
superior properties make it a good candidate for applications in various fields ranging from …

Correlating Mechanical Properties and Sequence Motifs in Artificial Spider Silk by Targeted Motif Substitution

H Nakamura, Y Ito, R Sato, H Chi, C Sato… - ACS Biomaterials …, 2024 - ACS Publications
The major ampullate silk of orb-weaving spiders is renowned for its exceptional mechanical
properties, including high tensile strength and extensibility. The development of artificial …

Effects of Mini-Spidroin Repeat Region on the Mechanical Properties of Artificial Spider Silk Fibers

B Schmuck, G Greco, O Shilkova, A Rising - ACS omega, 2024 - ACS Publications
Spiders can produce up to seven different types of silk, each with unique mechanical
properties that stem from variations in the repetitive regions of spider silk proteins …

On‐Demand Silk Protein‐Based Spray for Acute Burn Wound Management

Y Wang, K Nuutila, AH Carlsson… - Advanced Functional …, 2025 - Wiley Online Library
There is a critical unmet need to improve the treatment of battlefield burns. Rapid and
efficient wound protection and closure are essential to prevent infections, reduce pain, and …

Coacervates Composed of Low‐Molecular‐Weight Compounds–Molecular Design, Stimuli Responsiveness, Confined Reaction

SL Higashi, M Ikeda - Advanced Biology, 2025 - Wiley Online Library
The discovery of coacervation within living cells through liquid–liquid phase separation has
inspired scientists to investigate its fundamental principles and significance. Indeed …

Silk Proteins: Designs from Nature with Multipurpose Utility and Infinite Future Possibilities

K Numata, DL Kaplan - Advanced Materials, 2024 - Wiley Online Library
This is a Perspective on nature as a story‐teller, where inputs of evolution drove the
remarkable protein designs found in silks. This selection process has resulted in silk …

Functional Biomaterials Derived from Protein Liquid–Liquid Phase Separation and Liquid‐to‐Solid Transition

T Li, D Ilhamsyah, B Tai, Y Shen - Advanced Materials, 2025 - Wiley Online Library
Protein phase transitions play a vital role in both cellular functions and pathogenesis.
Dispersed proteins can undergo liquid–liquid phase separation to form condensates, a …