The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Microtubules act as “railways” for motor-driven intracellular transport, interact with accessory
proteins to assemble into larger structures such as the mitotic spindle, and provide an …

Mitochondrial fission is fundamentally important to cellular physiology. The dynamin-related
protein Drp1 mediates fission, and interaction between mitochondrion and endoplasmic …

The growth and migration of neurons require continuous remodelling of the neuronal
cytoskeleton, providing a versatile cellular framework for force generation and guided …

Formins are conserved actin polymerization machines that have instrumental roles in
controlling rearrangements of the actin cytoskeleton and have recently been shown to …

Cellular viability requires tight regulation of actin cytoskeletal dynamics. Distinct families of
nucleation-promoting factors enable the rapid assembly of filament nuclei that elongate and …

The small molecular inhibitor of formin FH2 domains, SMIFH2, is widely used in cell
biological studies. It inhibits formin-driven actin polymerization in vitro, but not …

Microtubules (MTs) govern actin network remodeling in a wide range of biological
processes, yet the mechanisms underlying this cytoskeletal cross-talk have remained …

Cell adhesion to the extracellular matrix is essential for cellular processes, such as migration
and invasion. In response to cues from the microenvironment, integrin-mediated adhesions …