This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The multifaceted role of biological membranes prompted early the development of artificial
lipid-based models with a primary view of reconstituting the natural functions in vitro so as to …

Lipid bilayer membranes form compartments requisite for life. Interfacing supramolecular
systems, including receptors, catalysts, signal transducers and ion transporters, enables the …

We present structures of mouse TRPV3 in temperature-dependent open, closed and
intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly …

Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons
project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses …

Testosterone is a key steroid hormone in the development of male reproductive tissues and
the regulation of the central nervous system. The rapid signaling mechanism induced by …

Bacterial populations harbor a small fraction of cells that display transient multidrug
tolerance. These so-called persister cells are extremely difficult to eradicate and contribute …

Ion attachment can modify stability and structure of phospholipid bilayers. Of particular
importance is the interaction of phospholipids with divalent cations, such as calcium ions …

Testosterone regulates dimorphic sexual behaviors in all vertebrates. However, the
molecular mechanism underlying these behaviors remains unclear. Here, we report that a …

Transport processes through ion-channel proteins, protein pores, or solid-state nanopores
are traditionally recorded with commercial patch-clamp amplifiers. The bandwidth of these …