[HTML][HTML] Bile acid–gut microbiota axis in inflammatory bowel disease: from bench to bedside

M Yang, Y Gu, L Li, T Liu, X Song, Y Sun, X Cao… - Nutrients, 2021‏ - mdpi.com
Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the
gastrointestinal tract, with increasing prevalence, and its pathogenesis remains unclear …

Cholestasis: Exploring the triangular relationship of gut microbiota-bile acid-cholestasis and the potential probiotic strategies

L Yu, Y Liu, S Wang, Q Zhang, J Zhao, H Zhang… - Gut …, 2023‏ - Taylor & Francis
Cholestasis is a condition characterized by the abnormal production or excretion of bile, and
it can be induced by a variety of causes, the factors of which are extremely complex …

EASL Clinical Practice Guidelines on sclerosing cholangitis

O Chazouilleres, U Beuers, A Bergquist, TH Karlsen… - Journal of …, 2022‏ - Elsevier
Management of primary or secondary sclerosing cholangitis is challenging. These Clinical
Practice Guidelines have been developed to provide practical guidance on debated topics …

Periportal macrophages protect against commensal-driven liver inflammation

Y Miyamoto, J Kikuta, T Matsui, T Hasegawa, K Fujii… - Nature, 2024‏ - nature.com
The liver is the main gateway from the gut, and the unidirectional sinusoidal flow from portal
to central veins constitutes heterogenous zones, including the periportal vein (PV) and the …

Bacteriophage therapy against pathological Klebsiella pneumoniae ameliorates the course of primary sclerosing cholangitis

M Ichikawa, N Nakamoto, S Kredo-Russo… - Nature …, 2023‏ - nature.com
Primary sclerosing cholangitis (PSC) is characterized by progressive biliary inflammation
and fibrosis. Although gut commensals are associated with PSC, their causative roles and …

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

N Nakamoto, N Sasaki, R Aoki, K Miyamoto… - Nature …, 2019‏ - nature.com
Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease and its frequent
complication with ulcerative colitis highlights the pathogenic role of epithelial barrier …

Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis

W Gui, MJ Hole, A Molinaro, K Edlund… - Nature …, 2023‏ - nature.com
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by
chronic inflammation and progressive fibrosis of the biliary tree. The majority of PSC patients …

[HTML][HTML] Inflammatory bowel disease and primary sclerosing cholangitis: one disease or two?

KN van Munster, A Bergquist, CY Ponsioen - Journal of Hepatology, 2024‏ - Elsevier
Primary sclerosing cholangitis (PSC) was declared one of the biggest unmet needs in
hepatology during International Liver Congress 2016 in Berlin. Since then, not much has …

Gut microbiome in primary sclerosing cholangitis: A review

R Little, E Wine, BM Kamath… - World journal of …, 2020‏ - pmc.ncbi.nlm.nih.gov
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by
biliary inflammation and stricturing. Exploration of the pathogenesis of PSC in light of its …

Alterations of the bile microbiome in primary sclerosing cholangitis

T Liwinski, R Zenouzi, C John, H Ehlken… - Gut, 2020‏ - gut.bmj.com
Background Patients with primary sclerosing cholangitis (PSC) display an altered colonic
microbiome compared with healthy controls. However, little is known on the bile duct …