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Therapeutic peptides: current applications and future directions
L Wang, N Wang, W Zhang, X Cheng, Z Yan… - Signal transduction and …, 2022 - nature.com
Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …
production, modification, and analytic technologies. Peptides have been produced and …
[HTML][HTML] Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics
Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …
produce aggressive malignancies that causes millions of deaths every year. With the new …
Multidrug resistance (MDR): A widespread phenomenon in pharmacological therapies
Multidrug resistance is a leading concern in public health. It describes a complex phenotype
whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic …
whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic …
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections
Y Zhu, W Hao, X Wang, J Ouyang… - Medicinal Research …, 2022 - Wiley Online Library
Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important
effector immune defense molecules in multicellular organisms. AMPs exert their …
effector immune defense molecules in multicellular organisms. AMPs exert their …
[HTML][HTML] A new era of antibiotics: the clinical potential of antimicrobial peptides
Antimicrobial resistance is a multifaceted crisis, imposing a serious threat to global health.
The traditional antibiotic pipeline has been exhausted, prompting research into alternate …
The traditional antibiotic pipeline has been exhausted, prompting research into alternate …
Antimicrobial peptides towards clinical application: Delivery and formulation
Antimicrobial peptides hold promise to supplement small molecules antibiotics and combat
the multidrug resistant microbes. There are however technical hurdles towards the clinical …
the multidrug resistant microbes. There are however technical hurdles towards the clinical …
Antimicrobial peptides: challenging journey to the pharmaceutical, biomedical, and cosmeceutical use
Antimicrobial peptides (AMPs), or host defence peptides, are short proteins in various life
forms. Here we discuss AMPs, which may become a promising substitute or adjuvant in …
forms. Here we discuss AMPs, which may become a promising substitute or adjuvant in …
The demand for new antibiotics: antimicrobial peptides, nanoparticles, and combinatorial therapies as future strategies in antibacterial agent design
The inappropriate use of antibiotics and an inadequate control of infections have led to the
emergence of resistant strains which represent a major threat to public health and the global …
emergence of resistant strains which represent a major threat to public health and the global …
Genome-resolved metagenomics: a game changer for microbiome medicine
N Kim, J Ma, W Kim, J Kim, P Belenky… - Experimental & Molecular …, 2024 - nature.com
Recent substantial evidence implicating commensal bacteria in human diseases has given
rise to a new domain in biomedical research: microbiome medicine. This emerging field …
rise to a new domain in biomedical research: microbiome medicine. This emerging field …
[HTML][HTML] Intracellular and extracellular lipopolysaccharide signaling in sepsis: avenues for novel therapeutic strategies
RS Gabarin, M Li, PA Zimmel, JC Marshall… - Journal of innate …, 2021 - karger.com
Sepsis is defined as organ dysfunction due to a dysregulated systemic host response to
infection. During gram-negative bacterial infection and other acute illness such as …
infection. During gram-negative bacterial infection and other acute illness such as …