Structure–activity relationships for ruthenium and osmium anticancer agents–towards clinical development
SM Meier-Menches, C Gerner, W Berger… - Chemical Society …, 2018 - pubs.rsc.org
Anticancer metallodrugs based on ruthenium and osmium are among the most investigated
and advanced non-platinum metallodrugs. Inorganic drug discovery with these agents has …
and advanced non-platinum metallodrugs. Inorganic drug discovery with these agents has …
Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs
W Liu, R Gust - Chemical Society Reviews, 2013 - pubs.rsc.org
The discovery of cisplatin's antitumor activity in 1969 prompted the search for novel metal-
containing complexes as potential anticancer drugs. Among these novel complexes, metal N …
containing complexes as potential anticancer drugs. Among these novel complexes, metal N …
Coinage Metal−N-Heterocyclic Carbene Complexes
JCY Lin, RTW Huang, CS Lee, A Bhattacharyya… - Chemical …, 2009 - ACS Publications
An N-heterocyclic carbene (NHC) contains a carbene carbon incorporated in a nitrogen-
containing heterocycle, presumably reactive and difficult to isolate. 1 The first isolation of …
containing heterocycle, presumably reactive and difficult to isolate. 1 The first isolation of …
The Medicinal applications of imidazolium carbene− metal complexes
Ofele and Wanzlick reported the synthesis of the first N-heterocyclic carbene (NHC)-metal
complexes in 1968. 1, 2 The isolation of the first free carbene by Arduengo in 1991 set the …
complexes in 1968. 1, 2 The isolation of the first free carbene by Arduengo in 1991 set the …
On the medicinal chemistry of gold complexes as anticancer drugs
I Ott - Coordination Chemistry Reviews, 2009 - Elsevier
Metal complexes have shown interesting preclinical and clinical results as antitumor drugs
and platinum compounds are well established in current cancer chemotherapy. However …
and platinum compounds are well established in current cancer chemotherapy. However …
Non platinum metal complexes as anti‐cancer drugs
I Ott, R Gust - Archiv der Pharmazie: An International Journal …, 2007 - Wiley Online Library
The development of metal complexes with platinum central atoms such as cisplatin or
carboplatin had an enormous impact on current cancer chemotherapy. However, the …
carboplatin had an enormous impact on current cancer chemotherapy. However, the …
Gold compounds as therapeutic agents for human diseases
SJ Berners-Price, A Filipovska - Metallomics, 2011 - academic.oup.com
The application of gold in medicine is traceable for several thousand years and Au (i)
compounds have been used clinically to treat rheumatoid arthritis since the last century …
compounds have been used clinically to treat rheumatoid arthritis since the last century …
A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds
From wedding rings on fingers to stained glass windows, by way of Olympic medals, gold
has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an …
has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an …
Phosphorescent iridium (III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents
Mitochondria-targeted compounds represent a promising approach to target tumors
selectively and overcome resistance to current anticancer therapies. In this work, three …
selectively and overcome resistance to current anticancer therapies. In this work, three …
Targeting the mitochondrial cell death pathway with gold compounds
There is much recent evidence showing that mitochondria play a critical role in the
regulation of apoptosis (programmed cell death), making them an attractive target for the …
regulation of apoptosis (programmed cell death), making them an attractive target for the …