The ubiquitin proteasome pathway is critical in restraining the activities of the p53 tumor
suppressor. Numerous E3 and E4 ligases regulate p53 levels. Additionally, deubquitinating …

Most cancers evolve to disable the p53 pathway, a key tumour suppressor mechanism that
prevents transformation and malignant cell growth. However, only~ 50% exhibit inactivating …

The transcription coactivator YAP plays a vital role in Hippo pathway for organ-size control
and tissue homeostasis. Recent studies have demonstrated YAP is closely related to …

Resistance to anoikis, cell death due to matrix detachment, is acquired during tumor
progression. The 14-3-3σ protein is implicated in the development of chemo-and radiation …

Aurora B is a mitotic checkpoint kinase that plays a pivotal role in the cell cycle, ensuring
correct chromosome segregation and normal progression through mitosis. Aurora B is …

Radiotherapy is the primary treatment for nasopharyngeal carcinoma (NPC), but
radioresistance severely reduces NPC radiocurability. Here, we have established a radio …

COP1 is an E3 ubiquitin ligase that is involved in the ubiquitylation of various protein
substrates to trigger their proteasomal degradation. Although originally identified in a light …

3-3 proteins are a family of conserved phospho-specific binding proteins involved in diverse
physiological processes. Plants have large 14-3-3 gene families, and many binding partners …

Metastasis is complex, involving multiple genetic, epigenetic, biochemical, and physical
changes in the cancer cell and its microenvironment. Cells with metastatic potential are often …

Nitrogen is an important factor that affects plant anthocyanin accumulation. In apple, the
nitrate-responsive BTB/TAZ protein MdBT2 negatively regulates anthocyanin biosynthesis …