Diabetes insipidus (DI) is a disorder characterized by excretion of large amounts of
hypotonic urine. Central DI results from a deficiency of the hormone arginine vasopressin …

The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …

Major depression is one of the leading causes of premature death and disability. Although
available drugs are effective, they also have substantial limitations. Recent advances in our …

Lithium is the most effective mood stabilizer for the treatment of bipolar disorder, but it is toxic
at only twice the therapeutic dosage and has many undesirable side effects. It is likely that a …

Lithium is widely used to treat bipolar disorder. Nephrogenic diabetes insipidus (NDI) is the
most common adverse effect of lithium and occurs in up to 40% of patients. Renal lithium …

Little is known regarding the mechanisms underlying the complex etiology of mood
disorders, represented mainly by major depressive disorder and bipolar disorder. The 1996 …

Zinc is a life‐sustaining trace element, serving structural, catalytic, and regulatory roles in
cellular biology. It is required for normal mammalian brain development and physiology …

COVID-19 is a rapidly spreading disease, which has caught the world by surprise. Millions of
people suffer from illness, and the mortality rates are dramatically high. Currently, there is no …

The circadian clock controls daily oscillations of gene expression at the cellular level. We
report the development of a high-throughput circadian functional assay system that consists …

Lithium has been used clinically to treat bipolar disorder for over half a century, and remains
a fundamental pharmacological therapy for patients with this illness. Although lithium's …