Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy
Single-molecule force spectroscopy has emerged as a powerful tool to investigate the forces
and motions associated with biological molecules and enzymatic activity. The most common …
and motions associated with biological molecules and enzymatic activity. The most common …
Probing the relation between force—lifetime—and chemistry in single molecular bonds
E Evans - Annual review of biophysics and biomolecular …, 2001 - annualreviews.org
▪ Abstract On laboratory time scales, the energy landscape of a weak bond along a
dissociation pathway is fully explored through Brownian-thermal excitations, and energy …
dissociation pathway is fully explored through Brownian-thermal excitations, and energy …
[HTML][HTML] Twisting and stretching single DNA molecules
The elastic properties of DNA are essential for its biological function. They control its
bending and twisting as well as the induction of structural modifications in the molecule …
bending and twisting as well as the induction of structural modifications in the molecule …
Single-molecule analysis of DNA uncoiling by a type II topoisomerase
Type II DNA topoisomerases are ubiquitous ATP-dependent enzymes capable of
transporting a DNA through a transient double-strand break in a second DNA segment. This …
transporting a DNA through a transient double-strand break in a second DNA segment. This …
Double-stranded RNA under force and torque: similarities to and striking differences from double-stranded DNA
RNA plays myriad roles in the transmission and regulation of genetic information that are
fundamentally constrained by its mechanical properties, including the elasticity and …
fundamentally constrained by its mechanical properties, including the elasticity and …
Quantitative modeling and optimization of magnetic tweezers
Magnetic tweezers are a powerful tool to manipulate single DNA or RNA molecules and to
study nucleic acid-protein interactions in real time. Here, we have modeled the magnetic …
study nucleic acid-protein interactions in real time. Here, we have modeled the magnetic …
Stretching of macromolecules and proteins
In this paper we review the biophysics revealed by stretching single biopolymers. During the
last decade various techniques have emerged allowing micromanipulation of single …
last decade various techniques have emerged allowing micromanipulation of single …
High-resolution, genome-wide map** of positive supercoiling in chromosomes
Supercoiling impacts DNA replication, transcription, protein binding to DNA, and the three-
dimensional organization of chromosomes. However, there are currently no methods to …
dimensional organization of chromosomes. However, there are currently no methods to …
[BOOK][B] Soft condensed matter physics in molecular and cell biology
WCK Poon, D Andelman - 2006 - taylorfrancis.com
Soft condensed matter physics, which emerged as a distinct branch of physics in the 1990s,
studies complex fluids: liquids in which structures with length scale between the molecular …
studies complex fluids: liquids in which structures with length scale between the molecular …
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair
Critical for transcription initiation and bulky lesion DNA repair, TFIIH provides an exemplary
system to connect molecular mechanisms to biological outcomes due to its strong genetic …
system to connect molecular mechanisms to biological outcomes due to its strong genetic …