Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy
L Yang, Z Chu, M Liu, Q Zou, J Li, Q Liu… - Journal of hematology & …, 2023 - Springer
Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …
How tolerogenic dendritic cells induce regulatory T cells
RA Maldonado, UH von Andrian - Advances in immunology, 2010 - Elsevier
Since their discovery by Steinman and Cohn in 1973, dendritic cells (DCs) have become
increasingly recognized for their crucial role as regulators of innate and adaptive immunity …
increasingly recognized for their crucial role as regulators of innate and adaptive immunity …
IL‐23 and the Th17 pathway promote inflammation and impair antifungal immune resistance
T Zelante, A De Luca, P Bonifazi… - European journal of …, 2007 - Wiley Online Library
Although inflammation is an essential component of the protective response to fungi, its
dysregulation may significantly worsen fungal diseases. We found here that the IL‐23/IL‐17 …
dysregulation may significantly worsen fungal diseases. We found here that the IL‐23/IL‐17 …
The indoleamine 2, 3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation
W Chen, X Liang, AJ Peterson, DH Munn… - The Journal of …, 2008 - journals.aai.org
Human plasmacytoid dendritic cells (PDCs) can drive naive, allogeneic CD4+ CD25− T cells
to differentiate into CD4+ CD25+ Foxp3+ regulatory T cells (Tregs). However, the …
to differentiate into CD4+ CD25+ Foxp3+ regulatory T cells (Tregs). However, the …
IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-κB activation
Abstract The immunoregulatory enzyme indoleamine 2, 3-dioxygenase (IDO) suppresses T-
cell responses and promotes immune tolerance in mammalian pregnancy, tumour …
cell responses and promotes immune tolerance in mammalian pregnancy, tumour …
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
Half a century ago, chronic granulomatous disease (CGD) was first described as a disease
fatally affecting the ability of children to survive infections. Various milestone discoveries …
fatally affecting the ability of children to survive infections. Various milestone discoveries …
Dendritic cell control of tolerogenic responses
One of the most fundamental problems in immunology is the seemingly schizophrenic ability
of the immune system to launch robust immunity against pathogens, while acquiring and …
of the immune system to launch robust immunity against pathogens, while acquiring and …
Role of indoleamine 2, 3-dioxygenase in health and disease
IDO1 (indoleamine 2, 3-dioxygenase 1) is a member of a unique class of mammalian haem
dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino …
dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino …
Overview on the prevalence of fungal infections, immune response, and microbiome role in COVID-19 patients
Patients with severe COVID-19, such as individuals in intensive care units (ICU), are
exceptionally susceptible to bacterial and fungal infections. The most prevalent fungal …
exceptionally susceptible to bacterial and fungal infections. The most prevalent fungal …
Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient-and donor …
The C-type lectin receptor Dectin-1 plays a pivotal role in antifungal immunity. In this study,
the recently characterized human DECTIN1 Y238X early stop codon polymorphism leading …
the recently characterized human DECTIN1 Y238X early stop codon polymorphism leading …