Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Celsus described four of the five cardinal signs of inflammation 2000 years ago, and
Eustachio discovered the adrenal glands almost 500 years ago, but not until 1936 did Selye …

Endotoxin, a constituent of Gram-negative bacteria, stimulates macrophages to release
large quantities of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate …

▪ Sepsis and its sequelae (sepsis syndrome and septic shock) are increasingly common and
are still potentially lethal diagnoses. Many mediators of the pathogenesis of sepsis have …

Sepsis and septic shock are among the leading causes of death in intensive care units
worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the …

Multiple organ failure (MOF) has reached epidemic proportions in most intensive care units
and is fast becoming the most common cause of death in the surgical intensive care unit …

Interleukin-6, an inflammatory cytokine, is characterized by pleiotropy and redundancy of
action. Apart from its hematologic, immune, and hepatic effects, it has many endocrine and …

Septic shock is the commonest cause of death in intensive care units. Although sepsis
usually produces a low systemic vascular resistance and elevated cardiac output, strong …

Objective.—To further define the safety and efficacy of recombinant human interleukin 1
receptor antagonist (rhIL-1ra) in the treatment of sepsis syndrome. Study Design …

Forty critically ill surgical patients with documented infections were studied during their stay
in an intensive care unit. Among these patients, 19 developed septic shock and 16 died, 9 of …