Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials

I Jantan, W Ahmad, SNA Bukhari - Frontiers in plant science, 2015 - frontiersin.org
The phagocyte–microbe interactions in the immune system is a defense mechanism but
when excessively or inappropriately deployed can harm host tissues and participate in the …

Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F

BJ Chen - Leukemia & lymphoma, 2001 - Taylor & Francis
Triptolide is a diterpenoid triepoxide purified from a Chines herb Tripterygium Wilfordii Hook
F (TWHF). TWHF has been used in traditional Chinese medicine for more than two thousand …

The continuing search for antitumor agents from higher plants

L Pan, H Chai, AD Kinghorn - Phytochemistry Letters, 2010 - Elsevier
Plant secondary metabolites and their semi-synthetic derivatives continue to play an
important role in anticancer drug therapy. In this short review, selected single chemical entity …

Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells

TM Kiviharju, PS Lecane, RG Sellers, DM Peehl - Clinical Cancer Research, 2002 - AACR
Interest in exploiting traditional medicines for prevention or treatment of cancer is increasing.
Extracts from the herb Tripterygium wilfordii hook F have been used in China for centuries to …

Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice

Q Liang, Y Ju, Y Chen, W Wang, J Li, L Zhang… - Arthritis research & …, 2016 - Springer
Background In this study, we sought to determine the cellular source of inducible nitric oxide
synthase (iNOS) induced in lymphatic endothelial cells (LECs) in response to tumor necrosis …

Interactions between natural health products and antiretroviral drugs: pharmacokinetic and pharmacodynamic effects

LS Lee, ASA Andrade, C Flexner - Clinical Infectious Diseases, 2006 - academic.oup.com
Concurrent use of natural health products (NHPs) with antiretroviral drugs (ARVs) is
widespread among human immunodeficiency virus-infected patients. This article reviews the …

The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells

J Li, J Li, F Zhang - Journal of ethnopharmacology, 2015 - Elsevier
Abstract Ethnopharmacological relevance Traditional Chinese herbal medicine (CHM) has a
long-history for treatment of various human diseases including tumors, infection …

Immunomodulation of autoimmune arthritis by herbal CAM

SH Venkatesha, R Rajaiah, BM Berman… - Evidence‐Based …, 2011 - Wiley Online Library
Rheumatoid arthritis (RA) is a debilitating autoimmune disease of global prevalence. The
disease is characterized by synovial inflammation leading to cartilage and bone damage …

Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells

Y Zhao, J He, J Li, X Peng, X Wang, Z Dong… - Cell death & …, 2017 - nature.com
Demethylzeylasteral is one of the extracts of Tripterygium wilfordii Hook F, which plays
important roles in multiple biological processes such as inflammation inhibition, as well as …

Herbal medicinal products target defined biochemical and molecular mediators of inflammatory autoimmune arthritis

SH Venkatesha, BM Berman, KD Moudgil - Bioorganic & medicinal …, 2011 - Elsevier
Rheumatoid arthritis (RA) is a chronic debilitating disease characterized by synovial
inflammation, damage to cartilage and bone, and deformities of the joints. Several drugs …