Glucose transporters at the blood-brain barrier: function, regulation and gateways for drug delivery

SG Patching - Molecular neurobiology, 2017 - Springer
Glucose transporters (GLUTs) at the blood-brain barrier maintain the continuous high
glucose and energy demands of the brain. They also act as therapeutic targets and provide …

Energy substrates for neurons during neural activity: a critical review of the astrocyte-neuron lactate shuttle hypothesis

CP Chih, EL Roberts Jr - Journal of Cerebral Blood Flow & …, 2003 - journals.sagepub.com
Glucose had long been thought to fuel oxidative metabolism in active neurons until the
recently proposed astrocyte-neuron lactate shuttle hypothesis (ANLSH) challenged this …

Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery

P Reinstrup, N Ståhl, P Mellergård, T Uski… - …, 2000 - journals.lww.com
OBJECTIVE The study was undertaken to measure baseline values for chemical markers in
human subjects during wakefulness, anesthesia, and neurosurgery, using intracerebral …

Glucose transporters: structure, function and consequences of deficiency

GK Brown - Journal of inherited metabolic disease, 2000 - Springer
There are two mechanisms for glucose transport across cell membranes. In the intestine and
renal proximal tubule, glucose is transported against a concentration gradient by a …

Fluctuations in brain glucose concentration during behavioral testing: dissociations between brain areas and between brain and blood

EC McNay, RC McCarty, PE Gold - Neurobiology of learning and memory, 2001 - Elsevier
Traditional beliefs about two aspects of glucose regulation in the brain have been
challenged by recent findings. First, the absolute level of glucose in the brain's extracellular …

Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease

M Bigl, MK Brückner, T Arendt, V Bigl… - Journal of neural …, 1999 - Springer
The activities of hexokinase, aldolase, pyruvate kinase, lactate dehydrogenase and glucose
6-phosphate dehydrogenase were determined in brains of patients with Alzheimer's disease …

Extracellular Glucose Concentrations in the Rat Hippocampus Measured byZero‐Net‐Flux: Effects of Microdialysis Flow Rate, Strain, andAge

EC McNay, PE Gold - Journal of neurochemistry, 1999 - Wiley Online Library
The concentration of glucose in the brain's extracellularfluid remains controversial, with
recent estimates and measurements rangingfrom 0.35 to 3.3 mM. In the present …

Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain—an immunohistochemical study

M Arluison, M Quignon, P Nguyen, B Thorens… - Journal of chemical …, 2004 - Elsevier
The aim of this work was to study the distribution and cellular localization of GLUT2 in the rat
brain by light and electron microscopic immunohistochemistry, whereas our ultrastructural …

Lactate as a biomarker for sleep

E Naylor, DV Aillon, BS Barrett, GS Wilson… - Sleep, 2012 - academic.oup.com
Abstract Study Objectives: An ideal biomarker for sleep should change rapidly with sleep
onset, remain at a detectably differential level throughout the sleep period, and exhibit a …

Coordination of multiple memory systems

PE Gold - Neurobiology of learning and memory, 2004 - Elsevier
On the basis of lesions of different brain areas, several neural systems appear to be
important for processing information regarding different types of learning and memory. This …