New angiogenic regulators produced by TAMs: perspective for targeting tumor angiogenesis
I Larionova, E Kazakova, T Gerashchenko… - Cancers, 2021 - mdpi.com
Simple Summary Since the targeting of a single pro-angiogenic factor fails to improve
oncological disease outcome, significant efforts have been made to identify new pro …
oncological disease outcome, significant efforts have been made to identify new pro …
Tumor angiogenesis revisited: regulators and clinical implications
Abstract Since Judah Folkman hypothesized in 1971 that angiogenesis is required for solid
tumor growth, numerous studies have been conducted to unravel the angiogenesis process …
tumor growth, numerous studies have been conducted to unravel the angiogenesis process …
Reciprocal analyses in zebrafish and medaka reveal that harnessing the immune response promotes cardiac regeneration
Zebrafish display a distinct ability to regenerate their heart following injury. However, this
ability is not shared by another teleost, the medaka. In order to identify cellular and …
ability is not shared by another teleost, the medaka. In order to identify cellular and …
Cellular and molecular mechanisms of inflammation‐induced angiogenesis
Blood vessel formation is a fundamental process for the development of organism and tissue
regeneration. Of importance, angiogenesis occurring during postnatal development is …
regeneration. Of importance, angiogenesis occurring during postnatal development is …
Immunological functions of the neuropilins and plexins as receptors for semaphorins
A Kumanogoh, H Kikutani - Nature reviews Immunology, 2013 - nature.com
Semaphorins were originally identified as axon-guidance molecules that function during
neuronal development. However, cumulative evidence indicates that semaphorins also …
neuronal development. However, cumulative evidence indicates that semaphorins also …
Semaphorins in health and disease
Cell-cell communication is pivotal to guide embryo development, as well as to maintain adult
tissues homeostasis and control immune response. Among extracellular factors responsible …
tissues homeostasis and control immune response. Among extracellular factors responsible …
The role of the semaphorins in cancer
G Neufeld, Y Mumblat, T Smolkin… - Cell Adhesion & …, 2016 - Taylor & Francis
The semaphorins were initially characterized as axon guidance factors, but have
subsequently been implicated also in the regulation of immune responses, angiogenesis …
subsequently been implicated also in the regulation of immune responses, angiogenesis …
Emerging roles and mechanisms of semaphorins activity in cancer
Semaphorins are regulatory molecules that are linked to the modulation of several cancer
processes, such as angiogenesis, cancer cell invasiveness and metastasis, tumor growth …
processes, such as angiogenesis, cancer cell invasiveness and metastasis, tumor growth …
Emerging role of semaphorins as major regulatory signals and potential therapeutic targets in cancer
L Tamagnone - Cancer cell, 2012 - cell.com
Semaphorins are mainly known as guidance signals in development, acting through
receptors called Plexins. However, their role in cancer is rapidly emerging in the regulation …
receptors called Plexins. However, their role in cancer is rapidly emerging in the regulation …
Semaphorins in angiogenesis and autoimmune diseases: therapeutic targets?
V Iragavarapu-Charyulu, E Wojcikiewicz… - Frontiers in …, 2020 - frontiersin.org
The axonal guidance molecules, semaphorins, have been described to function both
physiologically and pathologically outside of the nervous system. In this review, we focus on …
physiologically and pathologically outside of the nervous system. In this review, we focus on …