The expression of acute-phase proteins (APP's) maintains homeostasis and tissue repair,
but also represents a central component of the organism's defense strategy, especially in the …

In the Fall of 2019 a sudden and dramatic outbreak of a pulmonary disease (Coronavirus
Disease COVID-19), due to a new Coronavirus strain (ie, SARS-CoV-2), emerged in the …

Background: Host proteases have been suggested to be crucial for dissemination of MERS,
SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane …

At present, proven clinical treatments but no cures are available for diabetes, a global
epidemic with a huge economic burden. Transplantation of islets of Langerhans by their …

Acute phase proteins (APPs) are highly conserved plasma proteins that are increasingly
secreted by the liver in response to a variety of injuries, independently of their location and …

Understanding Covid‐19 pathophysiology is crucial for a better understanding of the
disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a …

Alpha-1 antitrypsin (A1AT) is an acute-phase protein, and is best known as an inhibitor of
the serine proteases, specifically, neutrophil elastase, proteinase 3, and cathepsin G. The …

Chronic metabolic diseases such as diabetes are characterized by delayed wound healing
and a dysregulation of the inflammatory phase of wound repair. Our study focuses on …

Alpha-1-antitrypsin (AAT), a serine protease inhibitor (serpin), is increasingly recognized to
inhibit SARS-CoV-2 infection and counter many of the pathogenic mechanisms of COVID …

Besides cancer and cardiovascular diseases, lung disorders are a leading cause of
morbidity and death worldwide. For many disease conditions no effective and curative …