[HTML][HTML] Digital pathology and artificial intelligence in translational medicine and clinical practice

V Baxi, R Edwards, M Montalto, S Saha - Modern Pathology, 2022 - Elsevier
Traditional pathology approaches have played an integral role in the delivery of diagnosis,
semi-quantitative or qualitative assessment of protein expression, and classification of …

DNA supramolecular assembly on micro/nanointerfaces for bioanalysis

C Yao, J Ou, J Tang, D Yang - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus Facing increasing demand for precision medicine, materials chemistry systems
for bioanalysis with accurate molecular design, controllable structure, and adjustable …

T lymphocyte-captured DNA network for localized immunotherapy

C Yao, C Zhu, J Tang, J Ou, R Zhang… - Journal of the American …, 2021 - ACS Publications
The efficient isolation of immune cells with high purity and low cell damage is important for
immunotherapy and remains highly challenging. We herein report a cell capture DNA …

Immunoscore immune checkpoint using spatial quantitative analysis of CD8 and PD-L1 markers is predictive of the efficacy of anti-PD1/PD-L1 immunotherapy in non …

F Ghiringhelli, F Bibeau, L Greillier, JD Fumet, A Ilie… - …, 2023 - thelancet.com
Summary Background Anti-PD-1 and PD-L1 antibodies (mAbs) are approved
immunotherapy agents to treat metastatic non-small cell lung cancer (NSCLC) patients. Only …

[HTML][HTML] Introduction to digital image analysis in whole-slide imaging: a white paper from the digital pathology association

F Aeffner, MD Zarella, N Buchbinder, MM Bui… - Journal of pathology …, 2019 - Elsevier
The advent of whole-slide imaging in digital pathology has brought about the advancement
of computer-aided examination of tissue via digital image analysis. Digitized slides can now …

Comparative analysis of assays to measure CAR T-cell-mediated cytotoxicity

S Kiesgen, JC Messinger, NK Chintala, Z Tano… - Nature protocols, 2021 - nature.com
The antitumor efficacy of genetically engineered 'living drugs', including chimeric antigen
receptor and T-cell receptor T cells, is influenced by their activation, proliferation, inhibition …

Looking beyond the hype: applied AI and machine learning in translational medicine

TS Toh, F Dondelinger, D Wang - EBioMedicine, 2019 - thelancet.com
Big data problems are becoming more prevalent for laboratory scientists who look to make
clinical impact. A large part of this is due to increased computing power, in parallel with new …

Multiplexed immunohistochemistry for molecular and immune profiling in lung cancer—just about ready for prime-time?

P Hofman, C Badoual, F Henderson, L Berland… - Cancers, 2019 - mdpi.com
As targeted molecular therapies and immuno-oncology have become pivotal in the
management of patients with lung cancer, the essential requirement for high throughput …

Development of DNA vaccine targeting E6 and E7 proteins of human papillomavirus 16 (HPV16) and HPV18 for immunotherapy in combination with recombinant …

S Peng, L Ferrall, S Gaillard, C Wang, WY Chi… - MBio, 2021 - Am Soc Microbiol
Immunotherapy for cervical cancer should target high-risk human papillomavirus types 16
and 18, which cause 50% and 20% of cervical cancers, respectively. Here, we describe the …

Automated image analysis of NSCLC biopsies to predict response to anti-PD-L1 therapy

S Althammer, TH Tan, A Spitzmüller, L Rognoni… - … for immunotherapy of …, 2019 - Springer
Abstract Background Immune checkpoint therapies (ICTs) targeting the programmed cell
death-1 (PD1)/programmed cell death ligand-1 (PD-L1) pathway have improved outcomes …