It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …

Backgrounds & Aims Increased permeability is implicated in the pathogenesis of intestinal
disease. In vitro and in vivo studies have linked down-regulation of the scaffolding protein …

Tissue differentiation is an important process that involves major cellular membrane
remodeling. We used Madin–Darby canine kidney cells as a model for epithelium formation …

A set of 11 clones encoding putative GTP binding proteins highly homqlogous to the yeast
YP7Y/SEC4 gene products have been isolated from an MDCK cell cDNA library. We …

Tuma, Pamela L., and Ann L. Hubbard. Transcytosis: Crossing Cellular Barriers. Physiol Rev
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …

Cell polarity is the ultimate reflection of complex mechanisms that establish and maintain
functionally specialized domains in the plasma membrane and cytoplasm. The spatial …

Ewkaryotic cells rapidly reorganize their microtubule cytoskeleton during the cell cycle,
differentiation, and cell migration. In this study, we have purified a heterodimeric protein …

The polarized distribution of functions in polarized cells requires the coordinated interaction
of three machineries that modify the basic mechanisms of intracellular protein trafficking and …

Proper organization of microtubule arrays is essential for intracellular trafficking and cell
motility. It is generally assumed that most if not all microtubules in vertebrate somatic cells …