The multistep translational science behind new drugs comprehends the entire process
through laboratory, clinical, and community observations turned into health interventions …

ABSTRACT Introduction Toxoplasma gondii, Trichomonas vaginalis, and Giardia intestinalis
are the causative agents of toxoplasmosis, trichomoniasis, and giardiasis, three important …

Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal
agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and …

Indomethacin (IND) as a non-selective cyclooxygenase 1 and 2 inhibitor administered orally
causes numerous adverse effects, mostly related to the gastrointestinal tract. Moreover …

One of the main problems of Chagas disease (CD), the parasitic infection caused by
Trypanosoma cruzi, is the lack of a completely satisfactory treatment, which is currently …

Indazole is a vital nitrogen-containing heterocyclic unit in organic and medicinal chemistry
research and a helpful precursor molecule for the production of various types of …

A novel category of hybrids, termed (Z)-6-methyl-3-(1-((1-(prop‑2-yn-1-yl)-1H-indazol-6-yl)
amino) ethylidene)-2H-pyran-2, 4 (3H)‑dione, was synthesized by reductive coupling of N …

Chagas disease is a prevalent health problem in Latin America which has received
insufficient attention worldwide. Current treatments for this disease, benznidazole and …

Background: Currently, there is no safe and effective vaccine against leishmaniasis and
existing therapies are inadequate due to high toxicity, cost and decreased efficacy caused …

Indazoles have previously been identified as molecules with antiprotozoal activity. In this
study, we evaluate the in vitro activity of thirteen 3-alkoxy-1-benzyl-5-nitroindazole …