The discoveries leading to our present understanding of the glutathione peroxidases (GPxs)
are recalled. The cytosolic GPx, now GPx1, was first described by Mills in 1957 and claimed …

The aminoacyl-tRNA synthetases are an essential and universally distributed family of
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …

The authors were asked by the Editors of ACS Chemical Biology to write an article titled
“Why Nature Chose Selenium” for the occasion of the upcoming bicentennial of the …

The selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) changes its
physical characteristics and biological functions during sperm maturation. PHGPx exists as a …

Significant progress has been made in the past four decades toward understanding the
structures and synthesis of bioactive peptides produced by microorganisms through the …

Selenium is an essential micronutrient in the diet of many life forms, including humans and
other mammals. Significant health benefits have been attributed to this element. It is rapidly …

Rat antizyme gene expression requires programmed, ribosomal frameshiffing. A novel
autoregulatory mechanism enables modulation of frameshiffing according to the cellular …

Mammalian thioredoxin reductases (TrxR) are dimers homologous to glutathione reductase
with a selenocysteine (SeCys) residue in the conserved C-terminal sequence-Gly-Cys …

We investigated the requirements for selenocysteine insertion at single or multiple UGA
codons in eukaryotic selenoproteins. Two functional SECIS elements were identified in the …

▪ Abstract Selenium is an essential trace element that is incorporated into proteins as
selenocysteine (Sec), the twenty-first amino acid. Sec is encoded by a UGA codon in the …