Actin on and around the Nucleus

PM Davidson, B Cadot - Trends in Cell Biology, 2021 - cell.com
Actin plays roles in many important cellular processes, including cell motility, organelle
movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the …

Principles of organelle positioning in motile and non-motile cells

J Kroll, J Renkawitz - EMBO reports, 2024 - embopress.org
Cells are equipped with asymmetrically localised and functionally specialised components,
including cytoskeletal structures and organelles. Positioning these components to specific …

Accessing activity and viscoelastic properties of artificial and living systems from passive measurement

TM Muenker, G Knotz, M Krüger, T Betz - Nature Materials, 2024 - nature.com
Living systems are complex dynamic entities that operate far from thermodynamic
equilibrium. Their active, non-equilibrium behaviour requires energy to drive cellular …

A diffusiophoretic mechanism for ATP-driven transport without motor proteins

B Ramm, A Goychuk, A Khmelinskaia, P Blumhardt… - Nature Physics, 2021 - nature.com
The healthy growth and maintenance of a biological system depends on the precise spatial
organization of molecules within the cell through the dissipation of energy. Reaction …

Contribution of cytoplasm viscoelastic properties to mitotic spindle positioning

J **e, J Najafi, R Le Borgne… - Proceedings of the …, 2022 - National Acad Sciences
Cells are filled with macromolecules and polymer networks that set scale-dependent viscous
and elastic properties to the cytoplasm. Although the role of these parameters in molecular …

The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization

RM Skory, AA Moverley, G Ardestani, Y Alvarez… - Nature …, 2023 - nature.com
During preimplantation development, contractile forces generated at the apical cortex
segregate cells into inner and outer positions of the embryo, establishing the inner cell mass …

Two mechanisms drive pronuclear migration in mouse zygotes

K Scheffler, J Uraji, I Jentoft, T Cavazza… - Nature …, 2021 - nature.com
A new life begins with the unification of the maternal and paternal chromosomes upon
fertilization. The parental chromosomes first become enclosed in two separate pronuclei …

Go with the flow–bulk transport by molecular motors

W Lu, VI Gelfand - Journal of cell science, 2023 - journals.biologists.com
Cells are the smallest building blocks of all living eukaryotic organisms, usually ranging from
a couple of micrometers (for example, platelets) to hundreds of micrometers (for example …

Cytoplasm's got moves

S Shamipour, S Caballero-Mancebo, CP Heisenberg - Developmental Cell, 2021 - cell.com
Cytoplasm is a gel-like crowded environment composed of various macromolecules,
organelles, cytoskeletal networks, and cytosol. The structure of the cytoplasm is highly …

Cytoplasmic forces functionally reorganize nuclear condensates in oocytes

A Al Jord, G Letort, S Chanet, FC Tsai… - Nature …, 2022 - nature.com
Cells remodel their cytoplasm with force-generating cytoskeletal motors. Their activity
generates random forces that stir the cytoplasm, agitating and displacing membrane-bound …