Rescuing the last-line polymyxins: achievements and challenges
Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
Overcoming the rising incidence and evolving mechanisms of antibiotic resistance by novel drug delivery approaches–an overview
Antimicrobial resistance is a normal evolutionary process for microorganisms. Antibiotics
exerted accelerated selective pressure that hasten bacterial resistance through mutation …
exerted accelerated selective pressure that hasten bacterial resistance through mutation …
COVID-19: Pathophysiology, treatment options, nanotechnology approaches, and research agenda to combating the SARS-CoV2 pandemic
V Bhavana, P Thakor, SB Singh, NK Mehra - Life sciences, 2020 - Elsevier
The recent corona virus disease (COVID-19) outbreak has claimed the lives of many around
the world and highlighted an urgent need for experimental strategies to prevent, treat and …
the world and highlighted an urgent need for experimental strategies to prevent, treat and …
Inhaled formulations and pulmonary drug delivery systems for respiratory infections
Respiratory infections represent a major global health problem. They are often treated by
parenteral administrations of antimicrobials. Unfortunately, systemic therapies of high-dose …
parenteral administrations of antimicrobials. Unfortunately, systemic therapies of high-dose …
Amorphous powders for inhalation drug delivery
For inhalation drug delivery, amorphous powder formulations offer the benefits of increased
bioavailability for poorly soluble drugs, improved biochemical stability for biologics, and …
bioavailability for poorly soluble drugs, improved biochemical stability for biologics, and …
Challenges and strategies in drug delivery systems for treatment of pulmonary infections
Inhalation therapy has been reported as the most effective treatment for respiratory bacterial
infections due to the increasing relevance of drug bioavailability. Drug delivery systems …
infections due to the increasing relevance of drug bioavailability. Drug delivery systems …
Influence of excipients on physical and aerosolization stability of spray dried high-dose powder formulations for inhalation
The aim of this study is to investigate the influence of excipients on physical and
aerosolization stability of spray dried Ciprofloxacin dry powder inhaler formulations. The …
aerosolization stability of spray dried Ciprofloxacin dry powder inhaler formulations. The …
Synergy of nebulized phage PEV20 and ciprofloxacin combination against Pseudomonas aeruginosa
Nebulization is currently used for delivery of antibiotics for respiratory infections.
Bacteriophages (or phages) are effective predators of pathogens including Pseudomonas …
Bacteriophages (or phages) are effective predators of pathogens including Pseudomonas …
Pulmonary delivery of emerging antibacterials for bacterial lung infections treatment
J Li, H Zheng, SSY Leung - Pharmaceutical research, 2023 - Springer
Bacterial infections in the respiratory tract are considered as one of the major challenges to
the public health worldwide. Pulmonary delivery is an attractive approach in the …
the public health worldwide. Pulmonary delivery is an attractive approach in the …
Mucin binding reduces colistin antimicrobial activity
Colistin has found increasing use in treating drug-resistant bacterial lung infections, but
potential interactions with pulmonary biomolecules have not been investigated. We …
potential interactions with pulmonary biomolecules have not been investigated. We …