Molecular dynamics simulation for all

SA Hollingsworth, RO Dror - Neuron, 2018 - cell.com
The impact of molecular dynamics (MD) simulations in molecular biology and drug discovery
has expanded dramatically in recent years. These simulations capture the behavior of …

RNA structural dynamics as captured by molecular simulations: a comprehensive overview

J Sponer, G Bussi, M Krepl, P Banáš, S Bottaro… - Chemical …, 2018 - ACS Publications
With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

UCSF ChimeraX: Structure visualization for researchers, educators, and developers

EF Pettersen, TD Goddard, CC Huang… - Protein …, 2021 - Wiley Online Library
UCSF ChimeraX is the next‐generation interactive visualization program from the Resource
for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX …

[HTML][HTML] Scalable molecular dynamics on CPU and GPU architectures with NAMD

JC Phillips, DJ Hardy, JDC Maia, JE Stone… - The Journal of …, 2020 - pubs.aip.org
NAMD is a molecular dynamics program designed for high-performance simulations of very
large biological objects on CPU-and GPU-based architectures. NAMD offers scalable …

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

X Chi, R Yan, J Zhang, G Zhang, Y Zhang, M Hao… - Science, 2020 - science.org
Develo** therapeutics against severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) could be guided by the distribution of epitopes, not only on the receptor binding …

ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome

AT Baker, RJ Boyd, D Sarkar, A Teijeira-Crespo… - Science …, 2021 - science.org
Vaccines derived from chimpanzee adenovirus Y25 (ChAdOx1), human adenovirus type 26
(HAdV-D26), and human adenovirus type 5 (HAdV-C5) are critical in combatting the severe …

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

R Yan, Y Zhang, Y Li, L **a, Y Guo, Q Zhou - Science, 2020 - science.org
Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for severe acute respiratory
syndrome–coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2) that is causing …

In situ architecture of the ER–mitochondria encounter structure

MR Wozny, A Di Luca, DR Morado, A Picco, R Khaddaj… - Nature, 2023 - nature.com
The endoplasmic reticulum and mitochondria are main hubs of eukaryotic membrane
biogenesis that rely on lipid exchange via membrane contact sites,–, but the underpinning …

[PDF][PDF] ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps

TI Croll - Acta Crystallographica Section D: Structural Biology, 2018 - journals.iucr.org
This paper introduces ISOLDE, a new software package designed to provide an intuitive
environment for high-fidelity interactive remodelling/refinement of macromolecular models …

Structures and mechanism of the plant PIN-FORMED auxin transporter

KL Ung, M Winkler, L Schulz, M Kolb, DP Janacek… - Nature, 2022 - nature.com
Auxins are hormones that have central roles and control nearly all aspects of growth and
development in plants,–. The proteins in the PIN-FORMED (PIN) family (also known as the …