[HTML][HTML] Biocatalysis

EL Bell, W Finnigan, SP France, AP Green… - Nature Reviews …, 2021 - nature.com
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

Photobiocatalytic strategies for organic synthesis

MA Emmanuel, SG Bender, C Bilodeau… - Chemical …, 2023 - ACS Publications
Biocatalysis has revolutionized chemical synthesis, providing sustainable methods for
preparing various organic molecules. In enzyme-mediated organic synthesis, most reactions …

Directed evolution: bringing new chemistry to life

FH Arnold - Angewandte Chemie (International Ed. in English), 2017 - pmc.ncbi.nlm.nih.gov
Tailor‐made: Discussed herein is the ability to adapt biology's mechanisms for innovation
and optimization to solving problems in chemistry and engineering. The evolution of nature's …

Where chemocatalysis meets biocatalysis: In water

H Gröger, F Gallou, BH Lipshutz - Chemical Reviews, 2022 - ACS Publications
Chemoenzymatic catalysis, by definition, involves the merging of sequential reactions using
both chemocatalysis and biocatalysis, typically in a single reaction vessel. A major …

Power of biocatalysis for organic synthesis

CK Winkler, JH Schrittwieser, W Kroutil - ACS central science, 2021 - ACS Publications
Biocatalysis, using defined enzymes for organic transformations, has become a common
tool in organic synthesis, which is also frequently applied in industry. The generally high …

Designing artificial metalloenzymes by tuning of the environment beyond the primary coordination sphere

C Van Stappen, Y Deng, Y Liu, H Heidari… - Chemical …, 2022 - ACS Publications
Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

The crucial role of methodology development in directed evolution of selective enzymes

G Qu, A Li, CG Acevedo‐Rocha, Z Sun… - Angewandte Chemie …, 2020 - Wiley Online Library
Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …

Extending the application of biocatalysis to meet the challenges of drug development

PN Devine, RM Howard, R Kumar… - Nature Reviews …, 2018 - nature.com
The pharmaceutical industry, driven by an increasing need to deliver new and more effective
medicines to patients, is increasingly turning to the use of engineered biocatalysts for both …

The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis

RA Sheldon, D Brady, ML Bode - Chemical science, 2020 - pubs.rsc.org
Enzymes are excellent catalysts that are increasingly being used in industry and academia.
This perspective is primarily aimed at synthetic organic chemists with limited experience …

Engineered cytochrome P450 for direct arylalkene-to-ketone oxidation via highly reactive carbocation intermediates

S Gergel, J Soler, A Klein, KH Schülke, B Hauer… - Nature Catalysis, 2023 - nature.com
Ketones are crucial intermediates in synthesis and frequent moieties in many products. The
direct regioselective synthesis of ketones from internal alkenes could simplify synthetic …