[HTML][HTML] Biocatalysis
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …
academia and across the chemical and pharmaceutical industries. Its success has been …
Photobiocatalytic strategies for organic synthesis
MA Emmanuel, SG Bender, C Bilodeau… - Chemical …, 2023 - ACS Publications
Biocatalysis has revolutionized chemical synthesis, providing sustainable methods for
preparing various organic molecules. In enzyme-mediated organic synthesis, most reactions …
preparing various organic molecules. In enzyme-mediated organic synthesis, most reactions …
Directed evolution: bringing new chemistry to life
FH Arnold - Angewandte Chemie (International Ed. in English), 2017 - pmc.ncbi.nlm.nih.gov
Tailor‐made: Discussed herein is the ability to adapt biology's mechanisms for innovation
and optimization to solving problems in chemistry and engineering. The evolution of nature's …
and optimization to solving problems in chemistry and engineering. The evolution of nature's …
Where chemocatalysis meets biocatalysis: In water
Chemoenzymatic catalysis, by definition, involves the merging of sequential reactions using
both chemocatalysis and biocatalysis, typically in a single reaction vessel. A major …
both chemocatalysis and biocatalysis, typically in a single reaction vessel. A major …
Power of biocatalysis for organic synthesis
Biocatalysis, using defined enzymes for organic transformations, has become a common
tool in organic synthesis, which is also frequently applied in industry. The generally high …
tool in organic synthesis, which is also frequently applied in industry. The generally high …
Designing artificial metalloenzymes by tuning of the environment beyond the primary coordination sphere
Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
The crucial role of methodology development in directed evolution of selective enzymes
Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …
Extending the application of biocatalysis to meet the challenges of drug development
PN Devine, RM Howard, R Kumar… - Nature Reviews …, 2018 - nature.com
The pharmaceutical industry, driven by an increasing need to deliver new and more effective
medicines to patients, is increasingly turning to the use of engineered biocatalysts for both …
medicines to patients, is increasingly turning to the use of engineered biocatalysts for both …
The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis
Enzymes are excellent catalysts that are increasingly being used in industry and academia.
This perspective is primarily aimed at synthetic organic chemists with limited experience …
This perspective is primarily aimed at synthetic organic chemists with limited experience …
Engineered cytochrome P450 for direct arylalkene-to-ketone oxidation via highly reactive carbocation intermediates
Ketones are crucial intermediates in synthesis and frequent moieties in many products. The
direct regioselective synthesis of ketones from internal alkenes could simplify synthetic …
direct regioselective synthesis of ketones from internal alkenes could simplify synthetic …