Classical models of perceptual decision-making assume that subjects use a single,
consistent strategy to form decisions, or that decision-making strategies evolve slowly over …

Control of actions allows adaptive, goal-directed behaviour. The basal ganglia, including the
subthalamic nucleus, are thought to play a central role in dynamically controlling actions …

The dorsal striatum is instrumental in regulating motor control and goal-directed behaviors.
The classical description of the two output pathways of the dorsal striatum highlights their …

The basal ganglia are essential for executing motor actions. How the basal ganglia engage
spinal motor networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons …

Trial history biases and lapses are two of the most common suboptimalities observed during
perceptual decision-making. These suboptimalities are routinely assumed to arise from …

Perceptual decisions rely on learned associations between sensory evidence and
appropriate actions, involving the filtering and integration of relevant inputs to prepare and …

Precision pharmacology aims to manipulate specific cellular interactions within complex
tissues. In this pursuit, we introduce DART. 2 (drug acutely restricted by tethering), a second …

Optogenetic stimulation of Adora2a receptor-expressing spiny projection neurons (A2A-
SPNs) in the striatum drives locomotor suppression and transient punishment, results …

The basal ganglia are known to control actions and modulate movements. Neuronal activity
in the two efferent pathways of the dorsal striatum is critical for appropriate behavioral …

The basal ganglia (BG) contribute to reinforcement learning (RL) and decision-making, but
unlike artificial RL agents, it relies on complex circuitry and dynamic dopamine modulation …