Since the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a
significant amount of research conducted to explore its regulatory role in the physiology and …

Life, as a dense manifestation of soft matter, undergoes changes in water content,
biomacromolecular concentrations, condensation and crowding due to volumetric …

Hemodynamic overload and dysregulation of cellular metabolism are involved in
development of calcific aortic valve disease (CAVD). However, how mechanical stress …

Skin fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM)
caused by fibrotic disorders of the skin. In recent years, ECM stiffness has emerged as a …

Cardiac fibroblasts (CFs) are essential for preserving myocardial integrity and function. They
can detect variations in cardiac tissue stiffness using various cellular mechanosensors …

The identification and analysis of network motifs has been widely used in the functional
analysis of signaling components, disease discovery and other fields. The positive feedback …

Cardiac fibrosis is a common pathology in cardiovascular diseases which are reported as
the leading cause of death globally. In recent decades, accumulating evidence has shown …

Peptide‐based drugs hold great potential for cancer treatment, and their effectiveness is
driven by mechanisms on how peptides target cancer cells and escape from potential …

Mechanosensitive ion channels are widely distributed in the heart, lung, bladder and other
tissues, and plays an important role in exercise-induced cardiovascular function promotion …

Cardiovascular diseases are currently the most common cause of death in developed
countries. Due to lifestyle and environmental factors, this problem is only expected to …