Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlap** and interdigitated …

During cerebellar development, the main portion of the cerebellar plate neuroepithelium
gives birth to Purkinje cells and interneurons, whereas the rhombic lip, the germinal zone at …

There has been significant advancement in various aspects of scientific knowledge
concerning the role of cerebellum in the etiopathogenesis of autism. In the current …

The coordinated spatial and temporal regulation of gene expression in the vertebrate neural
tube determines the identity of neural progenitors and the function and physiology of the …

The function of neuronal circuits relies on the properties of individual neuronal cells and
their synapses. We propose that a substantial degree of synapse formation and function is …

The extracellular matrix (ECM) surrounds cells in the brain, providing structural and
functional support. Emerging studies demonstrate that the ECM plays important roles during …

The decline of cognitive function has emerged as one of the greatest health threats of old
age. Age-related cognitive decline is caused by an impacted neuronal circuitry, yet the …

Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in
mammals and is controlled by specialized RNA-binding proteins. The misregulation of …