[HTML][HTML] Superoxide dismutase administration: A review of proposed human uses

AC Rosa, D Corsi, N Cavi, N Bruni, F Dosio - Molecules, 2021 - mdpi.com
Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant
defense against oxidative stress in the body. SOD supplementation may therefore trigger the …

Cellular evaluation of superoxide dismutase mimics as catalytic drugs: Challenges and opportunities

G Schanne, S Demignot, C Policar, N Delsuc - Coordination Chemistry …, 2024 - Elsevier
Oxidative stress is known to be associated with many pathologies including inflammation,
cancer, diabetes, etc. However, oxidative stress resulting from the imbalance between …

ROS scavenging of SOD/CAT mimics probed by EPR and reduction of lipid peroxidation in S. cerevisiae and mouse liver, under severe hydroxyl radical stress …

LB Menezes, BB Segat, H Tolentino, DC Pires… - Journal of inorganic …, 2023 - Elsevier
The interaction between Cu II, Fe III and Mn II complexes, derived from the ligands 1-[bis
(pyridine-2-ylmethyl) amino]-3-chloropropan-2-ol (hpclnol) and bis (pyridine-2-ylmethyl) …

In vivo visualization of enantioselective targeting of amyloid and improvement of cognitive function by clickable chiral metallohelices

Z Du, C Liu, Z Liu, H Song, P Scott, X Du, J Ren… - Chemical …, 2023 - pubs.rsc.org
The pathogenesis of Alzheimer's disease (AD) is closely related to several contributing
factors, especially amyloid-β (Aβ) aggregation. Bioorthogonal reactions provide a general …

The role of NAD and NAD precursors on longevity and lifespan modulation in the budding yeast, Saccharomyces cerevisiae

CK Odoh, X Guo, JT Arnone, X Wang, ZK Zhao - Biogerontology, 2022 - Springer
Molecular causes of aging and longevity interventions have witnessed an upsurge in the last
decade. The resurgent interests in the application of small molecules as potential …

[HTML][HTML] Antitumoral synergism between a copper (II) complex and cisplatin improves in vitro and in vivo anticancer activity against melanoma, lung and breast cancer …

D Mariani, Z Ghasemishahrestani, W Freitas… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background Intrinsic resistance of cancer cells is a major concern for the success of
chemotherapy, and this undesirable feature stimulates further research into the design of …

Mitigating methylglyoxal-induced glycation stress: the protective role of iron, copper, and manganese coordination compounds in Saccharomyces cerevisiae

MESF do Espírito Santo, BF Frascino… - Biochemical …, 2024 - portlandpress.com
Glycation-induced stress (G-iS) is a physiological phenomenon that leads to the formation of
advanced glycation end-products, triggering detrimental effects such as oxidative stress …

Iron and copper complexes with antioxidant activity as inhibitors of the metastatic potential of glioma cells

JF Guerreiro, MAGB Gomes, F Pagliari, J Jansen… - RSC …, 2020 - pubs.rsc.org
Gliomas are the most common type of primary brain tumors, presenting high mortality and
recurrence rates that highlight the need for the development of more efficient therapies. In …

Response and regulatory mechanisms of heat resistance in pathogenic fungi

W **ao, J Zhang, J Huang, C **n, MJ Li… - Applied Microbiology and …, 2022 - Springer
Both the increasing environmental temperature in nature and the defensive body
temperature response to pathogenic fungi during mammalian infection cause heat stress …

Scavenging of reactive species probed by EPR and ex-vivo nanomolar reduction of lipid peroxidation of manganese complexes

BB Segat, LB Menezes, R Cervo, R Cargnelutti… - Journal of Inorganic …, 2023 - Elsevier
Antioxidant activity toward H 2 O 2, anion radical superoxide, hydroxyl and DPPH (2, 2-
diphenyl-1-picrylhydrazyl) of two manganese complexes [Mn (III)(bpa) 2] Cl. H 2 O (1) and …