Hepatocellular carcinoma mechanisms associated with chronic HCV infection and the impact of direct-acting antiviral treatment
S Dash, Y Aydin, KE Widmer… - Journal of hepatocellular …, 2020 - Taylor & Francis
Hepatitis C virus (HCV) infection is the major risk factor for liver cirrhosis and hepatocellular
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …
[HTML][HTML] Metabolic dysfunction and cancer in HCV: Shared pathways and mutual interactions
Hepatitis C virus hijacks many host metabolic processes in an effort to aid viral replication.
The resulting hepatic metabolic dysfunction underpins many of the hepatic and extrahepatic …
The resulting hepatic metabolic dysfunction underpins many of the hepatic and extrahepatic …
Diagnostic accuracy of serum matrix metalloproteinase‐7 for biliary atresia
L Yang, Y Zhou, P Xu, R Mourya, H Lei, G Cao… - Hepatology, 2018 - journals.lww.com
Recent studies have indicated that a number of long noncoding RNAs (lncRNAs) are
dysregulated in hepatocellular carcinoma, while their aberrant expressions are associated …
dysregulated in hepatocellular carcinoma, while their aberrant expressions are associated …
Elimination of hepatitis C virus has limited impact on the functional and mitochondrial impairment of HCV-specific CD8+ T cell responses
A Aregay, SO Sekyere, K Deterding, K Port, J Dietz… - Journal of …, 2019 - Elsevier
Background & Aims Hepatitis C virus (HCV)-specific CD8+ T cells are functionally impaired
in chronic hepatitis C. Even though HCV can now be rapidly and sustainably cleared from …
in chronic hepatitis C. Even though HCV can now be rapidly and sustainably cleared from …
Reversal of immunity after clearance of chronic HCV infection—all reset?
Chronic viral infections cause deterioration of our immune system. However, since persistent
infections rarely can be eliminated, the reinvigoration capacity of an exhausted immune …
infections rarely can be eliminated, the reinvigoration capacity of an exhausted immune …
Immunomodulation of the natural killer cell phenotype and response during HCV infection
Hepatitis C virus (HCV) infection develops into chronic hepatitis in over two-thirds of acute
infections. While current treatments with direct-acting antivirals (DAAs) achieve HCV …
infections. While current treatments with direct-acting antivirals (DAAs) achieve HCV …
Hepatitis C virus and the host: a mutual endurance leaving indelible scars in the host's immunity
Hepatitis C virus (HCV) has spread worldwide, and it is responsible for potentially severe
chronic liver disease and primary liver cancer. Chronic infection remains for life if not …
chronic liver disease and primary liver cancer. Chronic infection remains for life if not …
Unmet needs in the post-DAA era: the risk and molecular mechanisms of hepatocellular carcinoma after HCV eradication
CF Huang, MH Awad, M Gal-Tanamy… - Clinical and Molecular …, 2024 - e-cmh.org
Hepatitis C virus (HCV) is one of the major etiologies of hepatocellular carcinoma with
approximately 30% of HCC being due to HCV infection worldwide. HCV eradication by …
approximately 30% of HCC being due to HCV infection worldwide. HCV eradication by …
Immunological mechanisms for hepatocellular carcinoma risk after direct-acting antiviral treatment of hepatitis C virus infection
Direct-acting antiviral agents (DAAs) that allow for rapid clearance of hepatitis C virus (HCV)
may evoke immunological changes. Some cases of rapid de novo hepatocellular carcinoma …
may evoke immunological changes. Some cases of rapid de novo hepatocellular carcinoma …
Proteomics reveals a global phenotypic shift of NK cells in HCV patients treated with direct‐acting antivirals
W Bi, A Kraft, S Engelskircher, J Mischke… - European Journal of …, 2023 - Wiley Online Library
Chronic hepatitis C virus (HCV) infections compromise natural killer (NK)‐cell immunity.
Direct‐acting antivirals (DAA) effectively eliminate HCV, but the long‐term effects on NK …
Direct‐acting antivirals (DAA) effectively eliminate HCV, but the long‐term effects on NK …