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Mechanisms underlying the beneficial effects of physical exercise on multiple sclerosis: focus on immune cells
B Zong, F Yu, X Zhang, W Zhao, S Li, L Li - Frontiers in Immunology, 2023 - frontiersin.org
Multiple sclerosis (MS) is a prevalent neuroimmunological illness that leads to neurological
disability in young adults. Although the etiology of MS is heterogeneous, it is well …
disability in young adults. Although the etiology of MS is heterogeneous, it is well …
The complexities of investigating mitochondria dynamics in multiple sclerosis and mouse models of MS
KC Atkinson, M Osunde… - Frontiers in Neuroscience, 2023 - frontiersin.org
Multiple sclerosis (MS) is a demyelinating, degenerating disorder of the central nervous
system (CNS) that is accompanied by mitochondria energy production failure. A loss of …
system (CNS) that is accompanied by mitochondria energy production failure. A loss of …
[HTML][HTML] Does siponimod exert direct effects in the central nervous system?
M Kipp - Cells, 2020 - mdpi.com
The modulation of the sphingosine 1-phosphate receptor is an approved treatment for
relapsing multiple sclerosis because of its anti-inflammatory effect of retaining lymphocytes …
relapsing multiple sclerosis because of its anti-inflammatory effect of retaining lymphocytes …
[HTML][HTML] Orchestrating Stress Responses in Multiple Sclerosis: A Role for Astrocytic IFNγ Signaling
ML Habean, KE Kaiser, JL Williams - International Journal of Molecular …, 2024 - mdpi.com
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease that is
characterized by the infiltration of peripheral immune cells into the central nervous system …
characterized by the infiltration of peripheral immune cells into the central nervous system …
[HTML][HTML] Liver kinase B1 functions as a regulator for neural development and a therapeutic target for neural repair
E Huang, S Li - Cells, 2022 - mdpi.com
The liver kinase B1 (LKB1), also known as serine/threonine kinase 11 (STK11) and Par-4 in
C. elegans, has been identified as a master kinase of AMPKs and AMPK-related kinases …
C. elegans, has been identified as a master kinase of AMPKs and AMPK-related kinases …
[HTML][HTML] Induction of BVR-A Expression by Korean Red Ginseng in Murine Hippocampal Astrocytes: Role of Bilirubin in Mitochondrial Function via the LKB1–SIRT1 …
S Moon, CH Kim, J Park, M Kim, HS Jeon, YM Kim… - Antioxidants, 2022 - mdpi.com
The beneficial effects of Korean red ginseng extract (KRGE) on the central nervous system
(CNS) have been reported. Among the CNS cells, astrocytes possess robust antioxidative …
(CNS) have been reported. Among the CNS cells, astrocytes possess robust antioxidative …
Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly increases disease severity in a mouse model of multiple sclerosis
The c-Jun amino terminal kinases (JNKs) regulate transcription, and studies suggest they
contribute to neuropathology in the EAE model of MS. To examine the role of the JNK3 …
contribute to neuropathology in the EAE model of MS. To examine the role of the JNK3 …
Dysregulation of polarity proteins in astrocyte reactivity
J Luo - Ageing research reviews, 2023 - Elsevier
Astrocytes are highly polarized neuroglial cells. Polarity is the basis for many of the diverse
roles that astrocytes play in the normal and injured brain. Astrocytes are generally dormant …
roles that astrocytes play in the normal and injured brain. Astrocytes are generally dormant …
Serum levels of lipocalin-2 are elevated at early times in African American relapsing remitting multiple sclerosis patients
S Kalinin, AI Boullerne, DL Feinstein - Journal of neuroimmunology, 2022 - Elsevier
Previous studies showed that depleting Liver Kinase-B1 (LKB1) from astrocytes increased
inflammatory factors lipocalin-2 (LCN2) and osteopontin (OPN) in EAE. A single nucleotide …
inflammatory factors lipocalin-2 (LCN2) and osteopontin (OPN) in EAE. A single nucleotide …
Liver kinase B1 rs9282860 polymorphism and risk for multiple sclerosis in White and Black Americans
AI Boullerne, MT Wallin, WJ Culpepper… - Multiple sclerosis and …, 2021 - Elsevier
Background We previously reported that the single nucleotide polymorphism (SNP)
rs9282860 in serine threonine kinase 11 (STK11) gene which codes for liver kinase B1 …
rs9282860 in serine threonine kinase 11 (STK11) gene which codes for liver kinase B1 …