Emerging structural insights into glycosyltransferase-mediated synthesis of glycans
Glycans linked to proteins and lipids play key roles in biology; thus, accurate replication of
cellular glycans is crucial for maintaining function following cell division. The fact that …
cellular glycans is crucial for maintaining function following cell division. The fact that …
The role of O-glycosylation in human disease
O-glycosylation is a highly frequent post-translation modification of proteins, with important
functional implications in both physiological and disease contexts. The biosynthesis of O …
functional implications in both physiological and disease contexts. The biosynthesis of O …
Molecular recognition of GalNAc in mucin-type O-glycosylation
I Sanz-Martinez, S Pereira, P Merino… - Accounts of Chemical …, 2023 - ACS Publications
Conspectus N-Acetylgalactosamine (GalNAc)-type O-glycosylation is an essential
posttranslational modification (PTM) that plays fundamental roles in biology. Malfunction of …
posttranslational modification (PTM) that plays fundamental roles in biology. Malfunction of …
Polypeptide GalNAc-Ts: from redundancy to specificity
Mucin-type O-glycosylation is a post-translational modification (PTM) that is predicted to
occur in more than the 80% of the proteins that pass through the Golgi apparatus. This PTM …
occur in more than the 80% of the proteins that pass through the Golgi apparatus. This PTM …
Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3
Abstract Polypeptide GalNAc-transferase T3 (GalNAc-T3) regulates fibroblast growth factor
23 (FGF23) by O-glycosylating Thr178 in a furin proprotein processing motif RHT178R↓ S …
23 (FGF23) by O-glycosylating Thr178 in a furin proprotein processing motif RHT178R↓ S …
The O-glycosylating enzyme GALNT2 acts as an oncogenic driver in non-small cell lung cancer
Q Hu, T Tian, Y Leng, Y Tang, S Chen, Y Lv… - Cellular & Molecular …, 2022 - Springer
Abstract Background N-Acetylgalactosaminyltransferases (GALNTs), the enzymes that
initiate mucin-type O-glycosylation, are closely associated with tumor occurrence and …
initiate mucin-type O-glycosylation, are closely associated with tumor occurrence and …
[HTML][HTML] Generating orthogonal glycosyltransferase and nucleotide sugar pairs as next-generation glycobiology tools
Protein glycosylation fundamentally impacts biological processes. Nontemplated
biosynthesis introduces unparalleled complexity into glycans that needs tools to understand …
biosynthesis introduces unparalleled complexity into glycans that needs tools to understand …
The effect of a methyl group on structure and function: Serine vs. threonine glycosylation and phosphorylation
JJ Barchi Jr, CN Strain - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
A variety of glycan structures cover the surface of all cells and are involved in myriad
biological processes, including but not limited to, cell adhesion and communication, protein …
biological processes, including but not limited to, cell adhesion and communication, protein …
Exploring Regulation of Protein O-Glycosylation in Isogenic Human HEK293 Cells by Differential O-Glycoproteomics*[S]
Most proteins trafficking the secretory pathway of metazoan cells will acquire GalNAc-type O-
glycosylation. GalNAc-type O-glycosylation is differentially regulated in cells by the …
glycosylation. GalNAc-type O-glycosylation is differentially regulated in cells by the …
NMR investigations of glycan conformation, dynamics, and interactions
Glycans are ubiquitous in nature, decorating our cells and serving as the initial points of
contact with any visiting entities. These glycan interactions are fundamental to host …
contact with any visiting entities. These glycan interactions are fundamental to host …