There are multiple reasons why the next generation of biological and medical studies
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …

Fungal species have dynamic genomes and often exhibit genomic plasticity in response to
stress. This genome plasticity often comes with phenotypic consequences that affect fitness …

Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent
alteration in cancer genomes,. However, it is still debated whether their prevalence is due to …

Functional genomic strategies have become fundamental for annotating gene function and
regulatory networks. Here, we combined functional genomics with proteomics by quantifying …

Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with
aneuploidy-induced cellular stresses remain largely unknown. Here, we induce …

Metabolism is deeply intertwined with aging. Effects of metabolic interventions on aging
have been explained with intracellular metabolism, growth control, and signaling. Studying …

We present Slice-PASEF, a novel mass spectrometry technology based on trapped ion
mobility separation of ions. Slice-PASEF allows to achieve the theoretical maximum of …

Protein glycosylation, a complex and heterogeneous post-translational modification that is
frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a …

Although implicated as deleterious in many organisms, aneuploidy can underlie rapid
phenotypic evolution. However, aneuploidy will be maintained only if the benefit outweighs …

How cells regulate protein levels is a central question of biology. Over the past decades,
molecular biology research has provided profound insights into the mechanisms and the …