Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …

IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance
mechanisms in autoreactive CD8 T cells. How autoimmune T cell populations arise and are …

Diabetes mellitus comprises a group of carbohydrate metabolism disorders that share a
common main feature of chronic hyperglycemia that results from defects of insulin secretion …

Diabetes mellitus is one of the major public health problems worldwide. Considerable recent
evidence suggests that the cellular reduction-oxidation (redox) imbalance leads to oxidative …

Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …

Innate immunity represents the semi-specific first line of defense and provides the initial host
response to tissue injury, trauma, and pathogens. Innate immunity activates the adaptive …

BACKGROUND A previous phase I study showed that the infusion of autologous Tregs
expanded ex vivo into patients with recent-onset type 1 diabetes (T1D) had an excellent …

Background: During the past decades, the prevalence of diabetes (DM) has increased
significantly, mainly as a result of continuous rise in the incidence of type 2 DM. According to …

Background Long-term trends in excess risk of death and cardiovascular outcomes have not
been extensively studied in persons with type 1 diabetes or type 2 diabetes. Methods We …