Genetic architectures of psychiatric disorders: the emerging picture and its implications
Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5
years, there has been unprecedented progress on the genetics of many of these conditions …
years, there has been unprecedented progress on the genetics of many of these conditions …
The polygenic architecture of schizophrenia—rethinking pathogenesis and nosology
Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …
Although the past two decades have seen limited improvement in the treatment of …
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
Genetics of schizophrenia: overview of methods, findings and limitations
Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular
genetic research has produced novel findings, infusing optimism about discovering the …
genetic research has produced novel findings, infusing optimism about discovering the …
Genome‐wide association study of schizophrenia in Ashkenazi Jews
Schizophrenia is a common, clinically heterogeneous disorder associated with lifelong
morbidity and early mortality. Several genetic variants associated with schizophrenia have …
morbidity and early mortality. Several genetic variants associated with schizophrenia have …
The role of genetics in the etiology of schizophrenia
This article introduces the reader to the genetics of schizophrenia: its background; the status
of a variety of genetic findings; new developments (which are many since the last review) 1; …
of a variety of genetic findings; new developments (which are many since the last review) 1; …
DNA methylation and schizophrenia: current literature and future perspective
Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea,
identity, and emotions. It has no central pathophysiological mechanism and precise …
identity, and emotions. It has no central pathophysiological mechanism and precise …
Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia
Pharmacological, genetic and expression studies implicate N-methyl-D-aspartate (NMDA)
receptor hypofunction in schizophrenia (SCZ). Similarly, several lines of evidence suggest …
receptor hypofunction in schizophrenia (SCZ). Similarly, several lines of evidence suggest …
Neurodevelopmental and neuropsychiatric disorders represent an interconnected molecular system
Many putative genetic factors that confer risk to neurodevelopmental disorders such as
autism spectrum disorders (ASDs) and X-linked intellectual disability (XLID), and to …
autism spectrum disorders (ASDs) and X-linked intellectual disability (XLID), and to …
Gene–environment interplay in the etiology of psychosis
Schizophrenia and other types of psychosis incur suffering, high health care costs and loss
of human potential, due to the combination of early onset and poor response to treatment …
of human potential, due to the combination of early onset and poor response to treatment …