The brain is a vital organ, susceptible to alterations under genetic influences and
environmental experiences. Social isolation (SI) acts as a stressor which results in …

Notable sex-differences exist between neural structures that regulate sexually dimorphic
behaviors such as reproduction and parenting. While anatomical differences have been well …

Current evidences support inflammation, oxidative and nitrogen stress, as well as brain-
derived neurotrophic factor (BDNF) signaling mechanisms as important in depression …

Background It has been documented that aerobic exercise (AE) has a positive effect on
improving cognitive function in type 2 diabetes (T2DM) patients. Here, we tried to explore …

This paper reviews recent work on the biological underpinnings of clinical depression
emphasizing the crucial role of immunoinflammatory and oxidative and nitrosative stress …

In the central nervous system, nitric oxide (NO), a free gas with multitudinous bioactivities, is
mainly produced from the oxidation of L-arginine by neuronal nitric oxide synthase (nNOS) …

Affective disorders including major depressive disorder (MDD), bipolar disorder (BPD), and
general anxiety affect more than 10% of population in the world. Notably, neuronal nitric …

Anxiety is common in patients suffering from chronic pain. Here, we report anxiety-like
behaviors in mouse models of chronic pain and reveal that nNOS-expressing neurons in …

Background: Adult hippocampal neurogenesis and synaptic plasticity are necessary for the
behavioral response to the selective serotonin reuptake inhibitor (SSRI) fluoxetine, but the …

Yueju confers antidepressant effects in a rapid and long-lasting manner, similar to ketamine.
CREB (cAMP-response element binding protein) signaling is implicated in depression …