Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40
years ago. Since that time, remarkable progress has been made in understanding its …

Early atherosclerosis features functional and structural changes in the endothelial barrier
function that affect the traffic of molecules and solutes between the vessel lumen and the …

Cell-cell junctions respond to mechanical forces by changing their organization and
function. To gain insight into the mechanochemical basis underlying junction …

During epithelial morphogenesis, E-cadherin adhesive junctions play an important part in
mechanically coupling the contractile cortices of cells together, thereby distributing the …

VE-cadherin is a component of endothelial cell-to-cell adherens junctions, and it has a key
role in the maintenance of vascular integrity. During embryo development, VE-cadherin is …

Epithelial cells display dynamic behaviours, such as rearrangement, movement and shape
changes, particularly during embryonic development and in equivalent processes in adults …

During epithelial tissue development, repair, and homeostasis, adherens junctions (AJs)
ensure intercellular adhesion and tissue integrity while allowing for cell and tissue …

Force sensing at cadherin-mediated adhesions is critical for their proper function. α-Catenin,
which links cadherins to actomyosin, has a crucial role in this mechanosensing process. It …

Cadherins are the principal adhesion proteins at intercellular junctions and function as the
biochemical Velcro that binds cells together. Besides this mechanical function, cadherin …

The blood-brain barrier (BBB) is the regulated interface between the peripheral circulation
and the central nervous system (CNS). Although originally observed by Paul Ehrlich in 1885 …