Malaria biology and disease pathogenesis: insights for new treatments

LH Miller, HC Ackerman, X Su, TE Wellems - Nature medicine, 2013 - nature.com
Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan,
claims the lives of nearly a million children each year in Africa alone and is a top public …

[PDF][PDF] The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-part II

TJ Schmidt, SA Khalid, AJ Romanha, TMA Alves… - 2012 - researchgate.net
Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

[LIBRO][B] Therapeutic use of medicinal plants and their extracts: volume 1

ANM Alamgir - 2017 - Springer
The textbook of “Phytochemistry and bioactive compounds”, Volume 2 of the series—
Therapeutic use of Medicinal Plants and their Extracts, has been written to meet the needs of …

Antimalarials from nature

K Kaur, M Jain, T Kaur, R Jain - Bioorganic & medicinal chemistry, 2009 - Elsevier
Malaria is a major public health problem mainly due to the development of resistance by the
most lethal causative parasitic species, Plasmodium falciparum to the mainstay drugs like …

Marine pharmacology in 2005–6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal …

AMS Mayer, AD Rodríguez, RGS Berlinck… - … et Biophysica Acta (BBA …, 2009 - Elsevier
BACKGROUND: The review presents the 2005–2006 peer-reviewed marine pharmacology
literature, and follows a similar format to the authors' 1998–2004 reviews. The preclinical …

Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A

RG Linington, BR Clark, EE Trimble… - Journal of natural …, 2009 - ACS Publications
As part of a continuing program to identify novel treatments for neglected parasitic diseases,
the Panama International Cooperative Biodiversity Group (ICBG) program has been …

Kinase inhibitors of marine origin

SB Bharate, SD Sawant, PP Singh… - Chemical …, 2013 - ACS Publications
The ocean occupies three-fourths of the Earth's surface and hosts approximately 80% of all
living species. In fact, some areas of the sea such as coral reefs possess a biodiversity …

Marine antimalarials

E Fattorusso, O Taglialatela-Scafati - Marine Drugs, 2009 - mdpi.com
Malaria is an infectious disease causing at least 1 million deaths per year, and,
unfortunately, the chemical entities available to treat malaria are still too limited. In this …

Screening marine natural products for new drug leads against trypanosomatids and malaria

M Álvarez-Bardón, Y Pérez-Pertejo, C Ordóñez… - Marine Drugs, 2020 - mdpi.com
Neglected Tropical Diseases (NTD) represent a serious threat to humans, especially for
those living in poor or develo** countries. Almost one-sixth of the world population is at …

Plasmodium Kinases As Targets For New-Generation Antimalarials

IS Lucet, A Tobin, D Drewry, AF Wilks… - Future medicinal …, 2012 - Taylor & Francis
There is an urgent need for the development of new antimalarial drugs with novel modes of
actions. The malarial parasite, Plasmodium falciparum, has a relatively small kinome of< …