Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

ADP-ribosylation is a post-translational modification of proteins catalyzed by ADP-
ribosyltransferases. It comprises the transfer of the ADP-ribose moiety from NAD+ to specific …

Summary Poly (ADP-ribos) ylation (PARylation) is a reversible posttranslational modification
found in higher eukaryotes. However, little is known about PARylation acceptor proteins …

Cells must be able to cope with the challenge of folding newly synthesized proteins and
refolding those that have become misfolded in the context of a crowded cytosol. One such …

Poly (ADP-ribosyl) ation is catalyzed by a family of enzymes known as PARPs. We describe
a method to characterize the human aspartic acid–and glutamic acid–ADP-ribosylated …

ADP-ribosylation of proteins is emerging as an important regulatory mechanism. Depending
on the family member, ADP-ribosyltransferases either conjugate a single ADP-ribose to a …

Biomolecular condensates are reversible compartments that form through a process called
phase separation. Post-translational modifications like ADP-ribosylation can nucleate the …

The functionality of DNA, RNA and proteins is altered dynamically in response to
physiological and pathological cues, partly achieved by their modification. While the …

Protein ADP-ribosylation is an ancient posttranslational modification with high biochemical
complexity. It alters the function of modified proteins or provides a scaffold for the recruitment …

ADP-ribosylation is a reversible post-translational modification with wide-ranging biological
functions in all kingdoms of life. A variety of enzymes use NAD+ to transfer either single or …