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Bioorthogonal chemistry for prodrug activation in vivo
Prodrugs have emerged as a major strategy for addressing clinical challenges by improving
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …
Bioorthogonal chemistry
SL Scinto, DA Bilodeau, R Hincapie, W Lee… - Nature Reviews …, 2021 - nature.com
Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …
rapidly and selectively in biological environments without side reactions towards …
Evolution of pyrrolysyl-tRNA synthetase: From methanogenesis to genetic code expansion
Over 20 years ago, the pyrrolysine encoding translation system was discovered in specific
archaea. Our Review provides an overview of how the once obscure pyrrolysyl-tRNA …
archaea. Our Review provides an overview of how the once obscure pyrrolysyl-tRNA …
Inverse electron demand Diels–Alder reactions in chemical biology
BL Oliveira, Z Guo, GJL Bernardes - Chemical Society Reviews, 2017 - pubs.rsc.org
The emerging inverse electron demand Diels–Alder (IEDDA) reaction stands out from other
bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and …
bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and …
Unleashing the power of bond cleavage chemistry in living systems
Bioorthogonal cleavage chemistry has been rapidly emerging as a powerful tool for
manipulation and gain-of-function studies of biomolecules in living systems. While the initial …
manipulation and gain-of-function studies of biomolecules in living systems. While the initial …
Artificial metalloenzymes: reaction scope and optimization strategies
F Schwizer, Y Okamoto, T Heinisch, Y Gu… - Chemical …, 2018 - ACS Publications
The incorporation of a synthetic, catalytically competent metallocofactor into a protein
scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late …
scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late …
Ligand-targeted drug delivery
M Srinivasarao, PS Low - Chemical reviews, 2017 - ACS Publications
Safety and efficacy constitute the major criteria governing regulatory approval of any new
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …
Residue-specific peptide modification: a chemist's guide
JN DeGruyter, LR Malins, PS Baran - Biochemistry, 2017 - ACS Publications
Advances in bioconjugation and native protein modification are appearing at a blistering
pace, making it increasingly time consuming for practitioners to identify the best chemical …
pace, making it increasingly time consuming for practitioners to identify the best chemical …
Single-Atom Catalysts Mediated Bioorthogonal Modulation of N6-Methyladenosine Methylation for Boosting Cancer Immunotherapy
Bioorthogonal reactions provide a powerful tool to manipulate biological processes in their
native environment. However, the transition-metal catalysts (TMCs) for bioorthogonal …
native environment. However, the transition-metal catalysts (TMCs) for bioorthogonal …
Polymerization of ethylene oxide, propylene oxide, and other alkylene oxides: synthesis, novel polymer architectures, and bioconjugation
J Herzberger, K Niederer, H Pohlit, J Seiwert… - Chemical …, 2016 - ACS Publications
The review summarizes current trends and developments in the polymerization of alkylene
oxides in the last two decades since 1995, with a particular focus on the most important …
oxides in the last two decades since 1995, with a particular focus on the most important …