Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor …

In mammals, excess energy is stored primarily as triglycerides, which are mobilized when
energy demands arise. This review mainly focuses on the role of long chain fatty acids …

Structural polymers are susceptible to damage in the form of cracks, which form deep within
the structure where detection is difficult and repair is almost impossible. Cracking leads to …

The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important
role in the control of gene expression linked to a variety of physiological processes. PPARγ …

Mice lacking the nuclear bile acid receptor FXR/BAR developed normally and were
outwardly identical to wild-type littermates. FXR/BAR null mice were distinguished from wild …

The nuclear hormone receptor superfamily includes receptors for thyroid and steroid
hormones, retinoids and vitamin D, as well as different “orphan” receptors of unknown …

The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated
transcription factors of the nuclear hormone receptor superfamily. They share a high degree …

We describe the discovery of an agonist of the nuclear receptor NR2F1 that specifically
activates dormancy programs in malignant cells. The agonist led to a self-regulated increase …

Nuclear receptors are multi-domain transcription factors that bind to DNA elements from
which they regulate gene expression. The peroxisome proliferator-activated receptors …

This chapter presents an overview of the current status of studies on the structural and
molecular biology of the retinoid X receptor subtypes α, β, and γ (RXRs, NR2B1–3), their …