A review of heterogeneity in attention deficit/hyperactivity disorder (ADHD)

Y Luo, D Weibman, JM Halperin, X Li - Frontiers in human …, 2019 - frontiersin.org
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that affects
approximately 8%–12% of children worldwide. Throughout an individual's lifetime, ADHD …

Unity and diversity of executive functions: Individual differences as a window on cognitive structure

NP Friedman, A Miyake - Cortex, 2017 - Elsevier
Executive functions (EFs) are high-level cognitive processes, often associated with the
frontal lobes, that control lower level processes in the service of goal-directed behavior …

Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories

CC Gross, A Schulte-Mecklenbeck… - Science Translational …, 2024 - science.org
One of the biggest challenges in managing multiple sclerosis is the heterogeneity of clinical
manifestations and progression trajectories. It still remains to be elucidated whether this …

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

PM Thompson, N Jahanshad, CRK Ching… - Translational …, 2020 - nature.com
This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …

Three Approaches to Understanding and Classifying Mental Disorder: ICD-11, DSM-5, and the National Institute of Mental Health's Research Domain Criteria (RDoC)

LA Clark, B Cuthbert… - … Science in the …, 2017 - journals.sagepub.com
The diagnosis of mental disorder initially appears relatively straightforward: Patients present
with symptoms or visible signs of illness; health professionals make diagnoses based …

Genetic insights into the neurodevelopmental origins of schizophrenia

R Birnbaum, DR Weinberger - Nature Reviews Neuroscience, 2017 - nature.com
Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …

Executive function in autism spectrum disorder: history, theoretical models, empirical findings, and potential as an endophenotype

EA Demetriou, MM DeMayo, AJ Guastella - Frontiers in psychiatry, 2019 - frontiersin.org
This review presents an outline of executive function (EF) and its application to autism
spectrum disorder (ASD). The development of the EF construct, theoretical models of EF …

Painful temporomandibular disorder: decade of discovery from OPPERA studies

GD Slade, R Ohrbach, JD Greenspan… - Journal of dental …, 2016 - journals.sagepub.com
In 2006, the OPPERA project (Orofacial Pain: Prospective Evaluation and Risk Assessment)
set out to identify risk factors for development of painful temporomandibular disorder (TMD) …

Social cognition in schizophrenia

MF Green, WP Horan, J Lee - Nature Reviews Neuroscience, 2015 - nature.com
Individuals with schizophrenia exhibit impaired social cognition, which manifests as
difficulties in identifying emotions, feeing connected to others, inferring people's thoughts …

Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics

AM Buch, C Liston - Neuropsychopharmacology, 2021 - nature.com
Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …