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[HTML][HTML] From genetic associations to genes: methods, applications, and challenges
Genome-wide association studies (GWASs) have identified numerous genetic loci
associated with human traits and diseases. However, pinpointing the causal genes remains …
associated with human traits and diseases. However, pinpointing the causal genes remains …
Massively parallel reporter assays and mouse transgenic assays provide complementary information about neuronal enhancer activity
Genetic studies find hundreds of thousands of noncoding variants associated with
psychiatric disorders. Massively parallel reporter assays (MPRAs) and in vivo transgenic …
psychiatric disorders. Massively parallel reporter assays (MPRAs) and in vivo transgenic …
Sex differences in brain cell-type specific chromatin accessibility in schizophrenia
Our understanding of the sex-specific role of the non-coding genome in serious mental
illness remains largely incomplete. To address this gap, we explored sex differences in …
illness remains largely incomplete. To address this gap, we explored sex differences in …
Genotype inference from aggregated chromatin accessibility data reveals genetic regulatory mechanisms
Background Understanding the genetic causes for variability in chromatin accessibility can
shed light on the molecular mechanisms through which genetic variants may affect complex …
shed light on the molecular mechanisms through which genetic variants may affect complex …