The nucleus is a dynamic environment containing chromatin, membraneless organelles,
and specialized molecular structures at the nuclear membrane. Within the spectrum of DNA …

Nuclear organization has emerged as a critical layer in the coordination of DNA repair
activities. Distinct types of DNA lesions have notably been shown to relocate at the vicinity of …

Abstract Nuclear Pore complexes (NPCs) act as docking sites to anchor particular DNA
lesions facilitating DNA repair by elusive mechanisms. Using replication fork barriers in …

Expanded CAG repeats form stem-loop secondary structures that lead to fork stalling and
collapse. Previous work has shown that these collapsed forks relocalize to nuclear pore …

Nuclear pore complexes (NPCs) have emerged as genome organizers, defining a particular
nuclear compartment enriched for SUMO protease and proteasome activities, and act as …

The four main types of biomolecules are nucleic acids, proteins, carbohydrates and lipids.
The knowledge about their respective interactions is as important as the individual …

Energy status in all eukaryotic cells is sensed by AMP-kinases. We have previously found
that the poly-histidine tract at the N-terminus of S. cerevisiae AMPK (Snf1) inhibits its function …

This review starts off with the first germline homozygous variants of the Nucleoporin 98 gene
(NUP98) in siblings whose clinical presentation recalls Rothmund–Thomson (RTS) and …

In eukaryotic cells, the genetic material is segregated inside the nucleus. This
compartmentalization of the genome requires a transport system that allows cells to move …

Components of the nuclear pore complex (NPC) have been shown to play a crucial role in
protecting against replication stress, and recovery from some types of stalled or collapsed …