Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …

Hepatitis C virus (HCV) remains a global public health problem even though more than 95%
of infections can be cured by treatment with direct-acting antiviral agents. Resolution of …

Autoinflammatory disease can result from monogenic errors of immunity. We describe a
patient with early-onset multi-organ immune dysregulation resulting from a mosaic, gain-of …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in
children is generally milder than in adults, but a proportion of cases result in …

The burden of malignancy related to viral infection is increasing in Sub-Saharan Africa
(SSA). In 2018, approximately 2 million new cancer cases worldwide were attributable to …

Most individuals exposed to hepatitis C virus (HCV) become persistently infected while a
minority spontaneously eliminate the virus. Although early immune events influence …

Hepatitis C virus (HCV) cure after all-oral direct-acting antiviral (DAA) therapy greatly
improves the liver and immune system. We aimed to assess the impact of this HCV …

To withstand complex microbial challenges, the mammalian gut largely depends on the
secretion of diverse antimicrobial proteins. Type III interferons (IFNλs) are ordinarily …

When interferons (IFNs) bind to their receptors, they upregulate numerous IFN-stimulated
genes (ISGs) with antiviral and immune regulatory activities. Hepatitis C virus (HCV) is a …

ABSTRACT Interferon lambda 4 (IFN-λ4) is a recently identified enigmatic member of the
interferon (IFN) lambda family. Genetic data suggest that the IFNL4 gene acts in a proviral …