The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms
against exogenous or endogenous stressors. Indeed, by increasing the expression of …

The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …

Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are clonal
hematopoietic stem cell diseases leading to an insufficient formation of functional blood …

Chemoresistance represents the main obstacle to cancer treatment with both conventional
and targeted therapy. Beyond specific molecular alterations, which can lead to targeted …

Nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that regulates redox
homeostasis, plays a pivotal role in several cellular processes such as cell proliferation and …

Nuclear factor‐erythroid 2‐related factor 2 (Nrf2) is a transcriptional signaling pathway that
plays a crucial role in numerous clinical complications. Pivotal roles of Nrf2 have been …

Cancer is one of the most fatal diseases with an increasing incidence and mortality all over
the world. Thus, there is an urgent need for novel therapies targeting major cancer-related …

Nuclear factor erythroid-2 related factor-2 (Nrf2) is an oxidative stress-response
transcriptional activator that promotes carcinogenesis through metabolic reprogramming …

Cancer is currently the most important problem endangering human health. As antitumor
drugs have always been the most common methods for treating cancers, searching for new …

Aging is accompanied by deficits in cognitive function and neuronal degeneration or loss.
Quercetin is a flavonoid that exhibits powerful antioxidant activity. This study evaluated the …