Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

The transmission and processing of pain signals relies critically on the activities of ion
channels that are expressed in afferent pain fibers. This includes voltage-gated channels, as …

Lysosomes require an acidic lumen between pH 4.5 and 5.0 for effective digestion of
macromolecules. This pH optimum is maintained by proton influx produced by the V-ATPase …

Highly efficient blue thermally activated delayed fluorescence molecules having 10H-
phenoxaborin and acridan units were reported. Pure blue emission peaking at around 450 …

Monday, February 19, 2018 303a neuronal excitability, respond to lipids, temperature and
mechanical stretch, and influence pain, temperature perception and anaesthetic responses …

Potassium channels participate in many biological functions, from ion homeostasis to
generation and modulation of the electrical membrane potential. They are involved in a …

Mechanical forces will have been omnipresent since the origin of life, and living organisms
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …

Potassium (K+) channels have been evolutionarily tuned for activation by diverse biological
stimuli, and pharmacological activation is thought to target these specific gating …

Abstract TASK-5 (KCNK15) belongs to the acid-sensitive subfamily of two-pore domain
potassium (K2P) channels, which includes TASK-1 and TASK-3. TASK-5 stands out as K2P …

TREK-1 is the most studied background K2P channel. Its main role is to control cell
excitability and maintain the membrane potential below the threshold of depolarization …