Sex disparities matter in cancer development and therapy

S Haupt, F Caramia, SL Klein, JB Rubin… - Nature Reviews …, 2021 - nature.com
Curing cancer through precision medicine is the paramount aim of the new wave of
molecular and genomic therapies. Currently, whether patients with non-reproductive …

[HTML][HTML] Chemical constituents of Panax ginseng and Panax notoginseng explain why they differ in therapeutic efficacy

H Liu, X Lu, Y Hu, X Fan - Pharmacological research, 2020 - Elsevier
Abstract Panax ginseng (Meyer) and Panax notoginseng (Burkill), belonging to the family
Araliaceae, are used worldwide as medicinal and functional herbs. Numerous publications …

Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

K Vijay - International immunopharmacology, 2018 - Elsevier
The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …

Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2

AS Wilson, KL Randall, JA Pettitt, JI Ellyard… - Nature …, 2022 - nature.com
Neutrophils perform critical functions in the innate response to infection, including through
the production of neutrophil extracellular traps (NETs)-web-like DNA structures which are …

The interferon (IFN) class of cytokines and the IFN regulatory factor (IRF) transcription factor family

H Negishi, T Taniguchi, H Yanai - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Interferons (IFNs) are a broad class of cytokines elicited on challenge to the host defense
and are essential for mobilizing immune responses to pathogens. Divided into three classes …

[HTML][HTML] Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases

JH Kim, YS Yi, MY Kim, JY Cho - Journal of ginseng research, 2017 - Elsevier
Panax ginseng is one of the most universally used herbal medicines in Asian and Western
countries. Most of the biological activities of ginseng are derived from its main constituents …

The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons

I Braasch, AR Gehrke, JJ Smith, K Kawasaki… - Nature …, 2016 - nature.com
To connect human biology to fish biomedical models, we sequenced the genome of spotted
gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome …

Immune sensing mechanisms that discriminate self from altered self and foreign nucleic acids

E Bartok, G Hartmann - Immunity, 2020 - cell.com
All lifeforms have developed highly sophisticated systems equipped to detect altered self
and non-self nucleic acids (NA). In vertebrates, NA-sensing receptors safeguard the integrity …

Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines

R Sartorius, M Trovato, R Manco, L D'Apice… - npj Vaccines, 2021 - nature.com
Toll-like receptors (TLRs) are transmembrane proteins belonging to the family of pattern-
recognition receptors. They function as sensors of invading pathogens through recognition …

A comparative review of toll-like receptor 4 expression and functionality in different animal species

C Vaure, Y Liu - Frontiers in immunology, 2014 - frontiersin.org
Toll-like receptors (TLRs) belong to the pattern recognition receptor (PRR) family, a key
component of the innate immune system. TLRs detect invading pathogens and initiate an …