The molecular origin of standard metabolic rate and thermogenesis in mammals is
examined. It is pointed out that there are important differences and distinctions between the …

We have seen that there is no simple answer to the question 'what controls respiration?'The
answer varies with (a) the size of the system examined (mitochondria, cell or organ),(b) the …

Key points Considerable controversy exists regarding the role of irisin, a putative exercise‐
induced myokine, in human metabolism. We therefore studied irisin and its precursor Fndc5 …

Since the initiation of work on mitochondrial Ca2+ transport in the early 1960s, the
relationship between experimental observations and physiological function has often …

Over the past years, a concept for creatine kinase function, the 'PCr-circuit'model, has
evolved. Based on this concept, multiple functions for the CK/PCr-system have been …

Within the skeletal muscle cell at the onset of muscular contraction, phosphocreatine (PCr)
represents the most immediate reserve for the rephosphorylation of adenosine triphosphate …

Proton pum** across the mitochondrial inner membrane and proton leak back through the
natural proton conductance pathway make up a futile cycle that dissipates redox energy. We …

Magnetic resonance spectroscopy (MRS) can give information about cellular metabolism in
vivo which is difficult to obtain in other ways. In skeletal muscle, non‐invasive 31 P MRS …

Insulin resistance correlates with intramyocellular lipid content (IMCL) and plasma free fatty
acids (FFAs) and was recently linked to mitochondrial dysfunction. We examined the …

In addition to direct assessment of high energy phosphorus containing metabolite content
within tissues, phosphorus magnetic resonance spectroscopy (31 P-MRS) provides options …