Mathematical models of blast-induced TBI: current status, challenges, and prospects

RK Gupta, A Przekwas - Frontiers in neurology, 2013 - frontiersin.org
Blast-induced traumatic brain injury (TBI) has become a signature wound of recent military
activities and is the leading cause of death and long-term disability among US soldiers. The …

Vascular and inflammatory factors in the pathophysiology of blast-induced brain injury

GA Elder, MA Gama Sosa, R De Gasperi… - Frontiers in …, 2015 - frontiersin.org
Blast-related traumatic brain injury (TBI) has received much recent attention because of its
frequency in the conflicts in Iraq and Afghanistan. This renewed interest has led to a rapid …

Development of a finite element model for blast brain injury and the effects of CSF cavitation

MB Panzer, BS Myers, BP Capehart… - Annals of biomedical …, 2012 - Springer
Blast-related traumatic brain injury is the most prevalent injury for combat personnel seen in
the current conflicts in Iraq and Afghanistan, yet as a research community, we still do not fully …

Mechanics of blast loading on the head models in the study of traumatic brain injury using experimental and computational approaches

S Ganpule, A Alai, E Plougonven… - … and modeling in …, 2013 - Springer
Blast waves generated by improvised explosive devices can cause mild, moderate to severe
traumatic brain injury in soldiers and civilians. To understand the interactions of blast waves …

Blast-induced biomechanical loading of the rat: an experimental and anatomically accurate computational blast injury model

A Sundaramurthy, A Alai, S Ganpule… - Journal of …, 2012 - liebertpub.com
Blast waves generated by improvised explosive devices (IEDs) cause traumatic brain injury
(TBI) in soldiers and civilians. In vivo animal models that use shock tubes are extensively …

Blast induces oxidative stress, inflammation, neuronal loss and subsequent short-term memory impairment in rats

HJ Cho, VSSS Sajja, PJ Vandevord, YW Lee - Neuroscience, 2013 - Elsevier
Molecular and cellular mechanisms of brain injury after exposure to blast overpressure
(BOP) are not clearly known. The present study hypothesizes that pro-oxidative and pro …

Primary blast causes mild, moderate, severe and lethal TBI with increasing blast overpressures: Experimental rat injury model

V Mishra, M Skotak, H Schuetz, A Heller, J Haorah… - Scientific reports, 2016 - nature.com
Injury severity in blast induced Traumatic Brain Injury (bTBI) increases with blast
overpressure (BOP) and impulse in dose-dependent manner. Pure primary blast waves …

Evolution of blast wave profiles in simulated air blasts: experiment and computational modeling

N Chandra, S Ganpule, NN Kleinschmit, R Feng… - Shock Waves, 2012 - Springer
Shock tubes have been extensively used in the study of blast traumatic brain injury due to
increased incidence of blast-induced neurotrauma in Iraq and Afghanistan conflicts. One of …

Primary blast brain injury mechanisms: current knowledge, limitations, and future directions

E Fievisohn, Z Bailey, A Guettler… - Journal of …, 2018 - asmedigitalcollection.asme.org
Mild blast traumatic brain injury (bTBI) accounts for the majority of brain injury in United
States service members and other military personnel worldwide. The mechanisms of primary …

Primary blast traumatic brain injury in the rat: relating diffusion tensor imaging and behavior

MD Budde, A Shah, M McCrea, WE Cullinan… - Frontiers in …, 2013 - frontiersin.org
The incidence of traumatic brain injury (TBI) among military personnel is at its highest point
in US history. Experimental animal models of blast have provided a wealth of insight into …