The hallucinogenic world of tryptamines: an updated review
In the area of psychotropic drugs, tryptamines are known to be a broad class of classical or
serotonergic hallucinogens. These drugs are capable of producing profound changes in …
serotonergic hallucinogens. These drugs are capable of producing profound changes in …
Chemistry and structure–activity relationships of psychedelics
DE Nichols - Behavioral Neurobiology of Psychedelic Drugs, 2018 - Springer
This chapter will summarize structure–activity relationships (SAR) that are known for the
classic serotonergic hallucinogens (aka psychedelics), focusing on the three chemical types …
classic serotonergic hallucinogens (aka psychedelics), focusing on the three chemical types …
Toxicology and analysis of psychoactive tryptamines
S Malaca, AF Lo Faro, A Tamborra, S Pichini… - International Journal of …, 2020 - mdpi.com
Our understanding of tryptamines is poor due to the lack of data globally. Tryptamines
currently are not part of typical toxicology testing regimens and their contribution to drug …
currently are not part of typical toxicology testing regimens and their contribution to drug …
Serotonergic functions in arousal and motor activity
MA Geyer - Behavioural brain research, 1995 - Elsevier
Changes in motor activity have long been used to characterize the effects of serotonergic
manipulations. The prevailing view has been that serotonin typically inhibits motor output …
manipulations. The prevailing view has been that serotonin typically inhibits motor output …
Structure–activity relationships of serotonin 5‐HT2A agonists
DE Nichols - Wiley Interdisciplinary Reviews: Membrane …, 2012 - Wiley Online Library
Of the 14 known types of serotonin receptors one of the most extensively studied is the 5‐
HT2A (5‐hydroxytryptamine) receptor. In the brain, this receptor plays a key role in …
HT2A (5‐hydroxytryptamine) receptor. In the brain, this receptor plays a key role in …
Increased anxiety and impaired memory in rats 3 months after administration of 3, 4-methylenedioxymethamphetamine (“ecstasy”)
Male Wistar rats were administered either (a) a high dose regime of 3, 4-
methylenedioxymethamphetamine (MDMA)(4× 5 mg/kg, ip over 4 h on each of 2 …
methylenedioxymethamphetamine (MDMA)(4× 5 mg/kg, ip over 4 h on each of 2 …
Differential contributions of dopamine D1, D2, and D3 receptors to MDMA-induced effects on locomotor behavior patterns in mice
VB Risbrough, VL Masten, S Caldwell… - …, 2006 - nature.com
Abstract MDMA or 'ecstasy'(3, 4-methylenedioxymethamphetamine) is a commonly used
psychoactive drug that has unusual and distinctive behavioral effects in both humans and …
psychoactive drug that has unusual and distinctive behavioral effects in both humans and …
Direct effects of 3, 4‐methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens …
We examined the effects of pressure ejected 3, 4‐methylenedioxymethamphetamine
(MDMA) from a micropipette on direct chemically stimulated release, and on electrically …
(MDMA) from a micropipette on direct chemically stimulated release, and on electrically …
α-Ethyltryptamine: A Ratiocinatory Review of a Forgotten Antidepressant
RA Glennon, M Dukat - ACS Pharmacology & Translational …, 2023 - ACS Publications
α-Ethyltryptamine (AET) is quite an interesting, but perhaps long-forgotten, centrally acting
agent. Known for more than 75 years, AET was once clinically available as an …
agent. Known for more than 75 years, AET was once clinically available as an …
Memantine prevents the cognitive impairment induced by 3, 4-methylenedioxymethamphetamine in rats
J Camarasa, JM Marimón, T Rodrigo… - European journal of …, 2008 - Elsevier
Amphetamine abuse is an important risk factor for the development of cognitive impairment
involving learning and memory. Since in previous studies we have demonstrated the …
involving learning and memory. Since in previous studies we have demonstrated the …