RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …

Understanding sex differences in physiology and disease requires the identification of the
molecular agents that cause phenotypic sex differences. Two groups of such agents are …

Sex differences are pervasive in human health and disease. One major key to sex-biased
differences lies in the sex chromosomes. Although the functions of the X chromosome …

Mutations in the RNA helicase, DDX3X, are a leading cause of Intellectual Disability and
present as DDX3X syndrome, a neurodevelopmental disorder associated with cortical …

Genetic networks are characterized by extensive buffering. During tumor evolution,
disruption of functional redundancies can create de novo vulnerabilities that are specific to …

The human DEAD-box protein DDX3X is an RNA remodelling enzyme that has been
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …

Alphaviruses are a large group of re-emerging arthropod-borne RNA viruses. The compact
viral RNA genomes harbor diverse structures that facilitate replication. These structures can …

Sex chromosomes are a fundamental aspect of sex-biased biology, but the extent to which
homologous X–Y gene pairs ('the gametologs') contribute to sex-biased phenotypes …

The innate immune response to viruses is critical for the correct establishment of protective
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …

DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA
biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for …